NP_008874.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,122 Da
NCBI Official Full Name
transcription factor SOX-12
NCBI Official Synonym Full Names
SRY (sex determining region Y)-box 12
NCBI Official Synonym Symbols
NCBI Protein Information
transcription factor SOX-12; SOX-22 protein; SRY-related HMG-box gene 22
UniProt Protein Name
Transcription factor SOX-12
UniProt Synonym Protein Names
Protein SOX-22
UniProt Synonym Gene Names
UniProt Entry Name
SOX12_HUMAN
NCBI Summary for SOX12
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]
UniProt Comments for SOX12
SOX12: Binds to the sequence 5'-AACAAT-3'.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: nucleus
Molecular Function: DNA binding
Biological Process: regulation of transcription from RNA polymerase II promoter; cell fate commitment; transcription, DNA-dependent; spinal cord development; positive regulation of transcription from RNA polymerase II promoter; protein-DNA complex assembly
Research Articles on SOX12
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Organs/Tissues associated with SOX12 elisa kit
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