NP_001041.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,007 Da
NCBI Official Full Name
somatostatin receptor type 2
NCBI Official Synonym Full Names
somatostatin receptor 2
NCBI Protein Information
somatostatin receptor type 2; SRIF-1; SS2R
UniProt Protein Name
Somatostatin receptor type 2
UniProt Synonym Protein Names
SRIF-1
UniProt Synonym Gene Names
UniProt Entry Name
SSR2_HUMAN
NCBI Summary for SSTR2
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]
UniProt Comments for SSTR2
SSTR2: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. The C-terminus interacts with SHANK1 PDZ domain. Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: 17q24
Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: neuropeptide binding; somatostatin receptor activity; protein binding; PDZ domain binding
Biological Process: peristalsis; regulation of muscle contraction; response to starvation; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; negative regulation of cell proliferation; cell-cell signaling; neuropeptide signaling pathway; forebrain development; digestion; cerebellum development; spermatogenesis; G-protein signaling, adenylate cyclase inhibiting pathway; response to nutrient
Research Articles on SSTR2
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Products associated with SSTR2 elisa kit
Pathways associated with SSTR2 elisa kit
Diseases associated with SSTR2 elisa kit
Organs/Tissues associated with SSTR2 elisa kit
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