NP_038862.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,413 Da
NCBI Official Full Name
secreted frizzled-related protein 1
NCBI Official Synonym Full Names
secreted frizzled-related protein 1
NCBI Official Synonym Symbols
sFRP-1; AW011917; AW107218; AW742929; 2210415K03Rik [Similar Products]
NCBI Protein Information
secreted frizzled-related protein 1
UniProt Protein Name
Secreted frizzled-related protein 1
UniProt Synonym Gene Names
UniProt Entry Name
SFRP1_MOUSE
UniProt Comments for SFRP1
SFRP1: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription. Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8. Down-regulated in colorectal and breast tumors. Up- regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions. Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. Belongs to the secreted frizzled-related protein (sFRP) family.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; cell surface; plasma membrane; extracellular region; intracellular; cytosol
Molecular Function: heparin binding; identical protein binding; Wnt-protein binding; protein binding; frizzled binding; cysteine-type endopeptidase activity; drug binding
Biological Process: neural tube development; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; somatic stem cell maintenance; multicellular organismal development; positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin; proteolysis; response to organic cyclic substance; negative regulation of insulin secretion; negative regulation of BMP signaling pathway; anterior/posterior pattern formation; negative regulation of ossification; positive regulation of smoothened signaling pathway; negative regulation of osteoblast differentiation; female gonad development; response to drug; negative regulation of peptidyl-tyrosine phosphorylation; somitogenesis; digestive tract morphogenesis; positive regulation of cell growth; negative regulation of fibroblast proliferation; negative regulation of bone remodeling; positive regulation of fat cell differentiation; hemopoietic progenitor cell differentiation; negative regulation of osteoblast proliferation; neural crest cell fate commitment; regulation of ossification; negative regulation of transcription, DNA-dependent; actin cytoskeleton organization and biogenesis; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of osteoclast differentiation; dorsal/ventral axis specification; negative regulation of cell proliferation; positive regulation of cell proliferation; hemopoiesis; cell differentiation; positive regulation of Wnt receptor signaling pathway; negative regulation of cell migration; negative regulation of epithelial cell proliferation; negative regulation of B cell differentiation; negative regulation of JNK activity; Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; male gonad development; development of primary male sexual characteristics; neural tube closure; negative regulation of cell growth
Research Articles on SFRP1
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Products associated with SFRP1 elisa kit
Pathways associated with SFRP1 elisa kit
Diseases associated with SFRP1 elisa kit
Organs/Tissues associated with SFRP1 elisa kit
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