NP_006071.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
88,889 Da
NCBI Official Full Name
semaphorin-3A
NCBI Official Synonym Full Names
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
NCBI Official Synonym Symbols
HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III [Similar Products]
NCBI Protein Information
semaphorin-3A
UniProt Protein Name
Semaphorin-3A
UniProt Synonym Protein Names
Semaphorin III; Sema III
UniProt Synonym Gene Names
UniProt Entry Name
SEM3A_HUMAN
NCBI Summary for SEMA3A
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]
UniProt Comments for SEMA3A
SEMA3A: Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. Belongs to the semaphorin family.
Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7p12.1
Cellular Component: membrane; axon; dendrite; extracellular region
Molecular Function: chemorepellent activity; receptor activity; semaphorin receptor binding
Biological Process: facial nerve structural organization; trigeminal nerve structural organization; axon guidance; apoptosis; regulation of heart rate; dendrite morphogenesis; olfactory bulb development; neuron migration; axonal fasciculation; negative chemotaxis; negative regulation of axon extension involved in axon guidance; axon extension involved in axon guidance; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; sympathetic nervous system development; branchiomotor neuron axon guidance; regulation of axon extension involved in axon guidance; nerve development; sensory system development
Disease: Hypogonadotropic Hypogonadism 16 With Or Without Anosmia
Research Articles on SEMA3A
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Products associated with SEMA3A elisa kit
Pathways associated with SEMA3A elisa kit
Diseases associated with SEMA3A elisa kit
Organs/Tissues associated with SEMA3A elisa kit
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