NP_000334.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,097 Da
NCBI Official Full Name
sodium/glucose cotransporter 1 isoform 1
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 1
NCBI Protein Information
sodium/glucose cotransporter 1
UniProt Protein Name
Sodium/glucose cotransporter 1
UniProt Synonym Protein Names
High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1
UniProt Synonym Gene Names
UniProt Entry Name
SC5A1_HUMAN
NCBI Summary for SLC5A1
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for SLC5A1
SLC5A1: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: apical plasma membrane; brush border membrane; integral to plasma membrane; intercellular junction; plasma membrane
Molecular Function: glucose:sodium symporter activity; protein binding
Biological Process: carbohydrate metabolic process; glucose transport; hexose transport; intestinal absorption; metanephros development; sodium ion transport; transmembrane transport
Disease: Glucose/galactose Malabsorption
Research Articles on SLC5A1
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Products associated with SLC5A1 elisa kit
Pathways associated with SLC5A1 elisa kit
Diseases associated with SLC5A1 elisa kit
Organs/Tissues associated with SLC5A1 elisa kit
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