NP_003095.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,812 Da
NCBI Official Full Name
sorbitol dehydrogenase
NCBI Official Synonym Full Names
sorbitol dehydrogenase
NCBI Protein Information
sorbitol dehydrogenase
UniProt Protein Name
Sorbitol dehydrogenase
UniProt Synonym Protein Names
L-iditol 2-dehydrogenase
UniProt Entry Name
DHSO_HUMAN
NCBI Summary for SORD
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
UniProt Comments for SORD
SORD: Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. Belongs to the zinc-containing alcohol dehydrogenase family.
Protein type: Oxidoreductase; Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.14
Chromosomal Location of Human Ortholog: 15q15.3
Cellular Component: cytosol; extracellular space; membrane; mitochondrial membrane
Molecular Function: carbohydrate binding; D-xylulose reductase activity; identical protein binding; L-iditol 2-dehydrogenase activity; NAD binding; zinc ion binding
Biological Process: carbohydrate metabolic process; fructose biosynthetic process; fructose metabolic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate; L-xylitol catabolic process; L-xylitol metabolic process; response to cadmium ion; response to copper ion; response to drug; response to hormone stimulus; response to nutrient levels; response to osmotic stress; sorbitol catabolic process; sperm motility
Research Articles on SORD
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Products associated with SORD elisa kit
Pathways associated with SORD elisa kit
Diseases associated with SORD elisa kit
Organs/Tissues associated with SORD elisa kit
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