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SPAST elisa kit :: Human Spastin (SPAST) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9313352 SPAST elisa kit
Unit / Price
48-Strip-Wells  /  $500 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,250 +4 FREE 8GB USB
10x96-Strip-Wells  /  $6,395 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Spastin (SPAST), ELISA Kit

★Popular Item★
 Also Known As   

Human Spastin (SPAST) ELISA Kit

 Product Gene Name   

SPAST elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 2; NC_000002.11 (32288680..32382706). Location: 2p24-p21
 OMIM    182601
 3D Structure    ModBase 3D Structure for Q9UBP0
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples.
 Assay Type    Sandwich (Quantitative)
 Detection Range    0.625 ng/ml - 20 ng/ml.
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SPAST elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SPAST purchase    MBS9313352 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Spastin (SPAST) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625 ng/ml - 20 ng/ml in biological research samples containing SPAST, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9313352 kit is based on SPAST antibody-SPAST antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SPAST antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SPAST. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for SPAST elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SPAST (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9313352. Click to request current manual
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NCBI/Uniprot data below describe general gene information for SPAST. It may not necessarily be applicable to this product.
 NCBI GI #    40806170
 NCBI GeneID    6683
 NCBI Accession #    NP_955468.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_199436.1 [Other Products]
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 UniProt Primary Accession #    Q9UBP0 [Other Products]
 UniProt Secondary Accession #    Q9UPR9; A7E2A7 [Other Products]
 UniProt Related Accession #    Q9UBP0 [Other Products]
 Molecular Weight    67,197 Da
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 NCBI Official Full Name    spastin isoform 2
 NCBI Official Synonym Full Names    spastin
 NCBI Official Symbol    SPAST [Similar Products]
 NCBI Official Synonym Symbols   
FSP2; SPG4; ADPSP
[Similar Products]
 NCBI Protein Information    spastin; spastic paraplegia 4 protein; spastic paraplegia 4 (autosomal dominant; spastin)
 UniProt Protein Name    Spastin
 UniProt Synonym Protein Names   
Spastic paraplegia 4 protein
 UniProt Gene Name    SPAST [Similar Products]
 UniProt Synonym Gene Names    ADPSP; FSP2; KIAA1083; SPG4 [Similar Products]
 UniProt Entry Name    SPAST_HUMAN
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 NCBI Summary for SPAST    This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SPAST    spastin: ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. May also play a role in axon growth and the formation of axonal branches. Defects in SPAST are the cause of spastic paraplegia autosomal dominant type 4 (SPG4). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG4 is the most common form of autosomal dominant spastic paraplegias. Belongs to the AAA ATPase family. Spastin subfamily. 4 isoforms of the human protein are produced by alternative promoter.

Protein type: Membrane protein, integral; EC 3.6.4.3; Cytoskeletal

Chromosomal Location of Human Ortholog: 2p24-p21

Cellular Component: microtubule cytoskeleton; centrosome; microtubule; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; integral to membrane; spindle; cytoplasmic vesicle; midbody; nucleus; endosome

Molecular Function: protein binding; microtubule binding; beta-tubulin binding; microtubule-severing ATPase activity; alpha-tubulin binding; ATP binding

Biological Process: positive regulation of microtubule depolymerization; ER to Golgi vesicle-mediated transport; axonogenesis; metabolic process; microtubule severing; microtubule bundle formation; protein homooligomerization; cytoplasmic microtubule organization and biogenesis

Disease: Spastic Paraplegia 4, Autosomal Dominant
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 Research Articles on SPAST    1. micro-rearrangements in the SPAST gene are a fairly frequent cause of hereditary spastic paraplaegia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SPAST elisa kitDiseases associated with SPAST elisa kit
 Reference Product  PubMed Publications
 ATL1 elisa kit  >29 publications with SPAST and ATL1
 NIPA1 elisa kit  >5 publications with SPAST and NIPA1
 ZFYVE27 elisa kit  >3 publications with SPAST and ZFYVE27
 RTN1 elisa kit  >2 publications with SPAST and RTN1
 NRF1 elisa kit  >1 publications with SPAST and NRF1
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >148 publications with SPAST and Congenital Abnormalities
 Nervous System Malformations Antibodies  >148 publications with SPAST and Nervous System Malformations
 Learning Disorders Antibodies  >2 publications with SPAST and Learning Disorders
 Autoimmune Diseases Antibodies  >2 publications with SPAST and Autoimmune Diseases
 Cardiovascular Diseases Antibodies  >2 publications with SPAST and Cardiovascular Diseases
 Spastic paraplegia 4, autosomal dominant Antibodies  >2 publications with SPAST and Spastic paraplegia 4, autosomal dominant
 Kidney Diseases Antibodies  >1 publications with SPAST and Kidney Diseases
Organs/Tissues associated with SPAST elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >27 publications with SPAST and Brain
 Muscle Antibodies  >15 publications with SPAST and Muscle
 Blood Antibodies  >6 publications with SPAST and Blood
 Connective Tissue Antibodies  >3 publications with SPAST and Connective Tissue
 Uterus Antibodies  >1 publications with SPAST and Uterus
 Skin Antibodies  >1 publications with SPAST and Skin
 Vascular Antibodies  >1 publications with SPAST and Vascular
 Kidney Antibodies  >1 publications with SPAST and Kidney
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