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TLX1 elisa kit :: Human T cell leukemia homeobox protein 1 (TLX1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7213257 TLX1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

T cell leukemia homeobox protein 1 (TLX1), ELISA Kit

 Also Known As   

Human T cell leukemia homeobox protein 1 (TLX1) ELISA Kit

 Product Gene Name   

TLX1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    186770
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TLX1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TLX1 purchase    MBS7213257 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the T cell leukemia homeobox protein 1 (TLX1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TLX1. The ELISA analytical biochemical technique of the MBS7213257 kit is based on TLX1 antibody-TLX1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TLX1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TLX1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for TLX1 elisa kit    Epigenetics and Nuclear Signaling
NCBI/Uniprot data below describe general gene information for TLX1. It may not necessarily be applicable to this product.
 NCBI GI #    399982
 NCBI GeneID    3195
 NCBI Accession #    P31314.1 [Other Products]
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 UniProt Secondary Accession #    O75699; Q5VXP2; Q9HCA0; Q9UD59; A1L4G3 [Other Products]
 UniProt Related Accession #    P31314 [Other Products]
 Molecular Weight    26,245 Da
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 NCBI Official Full Name    T-cell leukemia homeobox protein 1
 NCBI Official Synonym Full Names    T-cell leukemia homeobox 1
 NCBI Official Symbol    TLX1 [Similar Products]
 NCBI Official Synonym Symbols   
TCL3; HOX11
[Similar Products]
 NCBI Protein Information    T-cell leukemia homeobox protein 1; proto-oncogene TCL-3; homeobox protein Hox-11; T-cell leukemia/lymphoma protein 3; homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch)
 UniProt Protein Name    T-cell leukemia homeobox protein 1
 UniProt Synonym Protein Names   
Homeobox protein Hox-11; Proto-oncogene TCL-3; T-cell leukemia/lymphoma protein 3
 Protein Family    T-cell leukemia homeobox protein
 UniProt Gene Name    TLX1 [Similar Products]
 UniProt Synonym Gene Names    HOX11; TCL3 [Similar Products]
 UniProt Entry Name    TLX1_HUMAN
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 NCBI Summary for TLX1    This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
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 UniProt Comments for TLX1    TLX1: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: nucleus

Molecular Function: protein binding; protein heterodimerization activity; sequence-specific DNA binding

Biological Process: neuron differentiation; spleen development; organ formation; cell fate commitment; central nervous system development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter
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 Research Articles on TLX1    1. The occurrence of G-quadruplex structures at the HOX11 breakpoint region explain its fragility during the t(10;14) translocation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TLX1 elisa kitPathways associated with TLX1 elisa kit
 Reference Product  PubMed Publications
 PAX2 elisa kit  >9 publications with TLX1 and PAX2
 NUP214 elisa kit  >8 publications with TLX1 and NUP214
 MEIS1 elisa kit  >3 publications with TLX1 and MEIS1
 ETS1 elisa kit  >2 publications with TLX1 and ETS1
 TLE1 elisa kit  >2 publications with TLX1 and TLE1
 PHF6 elisa kit  >1 publications with TLX1 and PHF6
 CYP2C9 elisa kit  >1 publications with TLX1 and CYP2C9
 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with TLX1 elisa kitOrgans/Tissues associated with TLX1 elisa kit
 Disease Name  Pubmed Publications
 Leukemia-Lymphoma, Adult T-Cell Antibodies  >41 publications with TLX1 and Leukemia-Lymphoma, Adult T-Cell
 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >35 publications with TLX1 and Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
 Cell Transformation, Neoplastic Antibodies  >18 publications with TLX1 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >9 publications with TLX1 and Nervous System Diseases
 Aneuploidy Antibodies  >8 publications with TLX1 and Aneuploidy
 Disease Models, Animal Antibodies  >7 publications with TLX1 and Disease Models, Animal
 Splenic Diseases Antibodies  >3 publications with TLX1 and Splenic Diseases
 Embryo Loss Antibodies  >3 publications with TLX1 and Embryo Loss
 Skin Diseases Antibodies  >3 publications with TLX1 and Skin Diseases
 Atrophy Antibodies  >2 publications with TLX1 and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with TLX1 and Brain
 Intestine Antibodies  >4 publications with TLX1 and Intestine
 Stomach Antibodies  >2 publications with TLX1 and Stomach
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