P31314.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,245 Da
NCBI Official Full Name
T-cell leukemia homeobox protein 1
NCBI Official Synonym Full Names
T-cell leukemia homeobox 1
NCBI Official Synonym Symbols
NCBI Protein Information
T-cell leukemia homeobox protein 1; proto-oncogene TCL-3; homeobox protein Hox-11; T-cell leukemia/lymphoma protein 3; homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch)
UniProt Protein Name
T-cell leukemia homeobox protein 1
UniProt Synonym Protein Names
Homeobox protein Hox-11; Proto-oncogene TCL-3; T-cell leukemia/lymphoma protein 3
UniProt Synonym Gene Names
UniProt Entry Name
TLX1_HUMAN
NCBI Summary for TLX1
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
UniProt Comments for TLX1
TLX1: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; DNA-binding
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: nucleus
Molecular Function: protein binding; protein heterodimerization activity; sequence-specific DNA binding
Biological Process: neuron differentiation; spleen development; organ formation; cell fate commitment; central nervous system development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter
Research Articles on TLX1
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Products associated with TLX1 elisa kit
Pathways associated with TLX1 elisa kit
Diseases associated with TLX1 elisa kit
Organs/Tissues associated with TLX1 elisa kit
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