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TIAM2 elisa kit :: Human T-cell lymphoma invasion and metastasis 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9320560 TIAM2 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

T-cell lymphoma invasion and metastasis 2 (TIAM2), ELISA Kit

★Popular Item★
 Also Known As   

Human T-lymphoma invasion and metastasis-inducing protein 2, TIAM2 ELISA Kit

 Product Synonym Names    Human T-lymphoma invasion and metastasis-inducing protein 2 (TIAM2) ELISA kit; RP3-414L4.2; FLJ41865; STEF; SIF and TIAM1-like exchange factor; T-cell lymphoma invasion and metastasis 2
 Product Gene Name   

TIAM2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    604709
 3D Structure    ModBase 3D Structure for Q8IVF5
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples.
 Assay Type    Sandwich (Quantitative)
 Detection Range    0.625 ng/ml - 20 ng/ml.
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TIAM2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TIAM2 purchase    MBS9320560 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the T-cell lymphoma invasion and metastasis 2 (TIAM2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625 ng/ml - 20 ng/ml in biological research samples containing TIAM2, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9320560 kit is based on TIAM2 antibody-TIAM2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TIAM2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TIAM2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TIAM2 elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TIAM2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9320560. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TIAM2. It may not necessarily be applicable to this product.
 NCBI GI #    58331189
 NCBI GeneID    26230
 NCBI Accession #    NP_001010927.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001010927.2 [Other Products]
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 UniProt Primary Accession #    Q8IVF5 [Other Products]
 UniProt Secondary Accession #    Q6NXN9; Q6ZUP9; Q9UFG6; Q9UKV9; Q9UKW0; B2RP56; C9JZV2 [Other Products]
 UniProt Related Accession #    Q8IVF5 [Other Products]
 Molecular Weight    190,103 Da
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 NCBI Official Full Name    T-lymphoma invasion and metastasis-inducing protein 2 isoform b
 NCBI Official Synonym Full Names    T-cell lymphoma invasion and metastasis 2
 NCBI Official Symbol    TIAM2 [Similar Products]
 NCBI Official Synonym Symbols   
STEF; TIAM-2
[Similar Products]
 NCBI Protein Information    T-lymphoma invasion and metastasis-inducing protein 2; SIF and TIAM1-like exchange factor
 UniProt Protein Name    T-lymphoma invasion and metastasis-inducing protein 2
 UniProt Synonym Protein Names   
SIF and TIAM1-like exchange factor
 Protein Family    T-lymphoma invasion and metastasis-inducing protein
 UniProt Gene Name    TIAM2 [Similar Products]
 UniProt Synonym Gene Names    KIAA2016; STEF; TIAM-2 [Similar Products]
 UniProt Entry Name    TIAM2_HUMAN
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 NCBI Summary for TIAM2    This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TIAM2    TIAM2: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA. Belongs to the TIAM family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; Apoptosis; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 6q25.2

Cellular Component: growth cone; membrane; lamellipodium; cytosol; filopodium

Molecular Function: Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; receptor signaling protein activity; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; cellular lipid metabolic process
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 Research Articles on TIAM2    1. TIAM2 expression was undetectable in normal human liver but was induced in all HCC cell lines and in 86% (78/91) of HCC biopsies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TIAM2 elisa kitDiseases associated with TIAM2 elisa kit
 Products by Pathway  Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with TIAM2 and Neoplasms
 Adenocarcinoma Antibodies  >1 publications with TIAM2 and Adenocarcinoma
 Neurobehavioral Manifestations Antibodies  >1 publications with TIAM2 and Neurobehavioral Manifestations
 Liver Diseases Antibodies  >1 publications with TIAM2 and Liver Diseases
 Bone Diseases Antibodies  >1 publications with TIAM2 and Bone Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with TIAM2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with TIAM2 and Liver Neoplasms
Organs/Tissues associated with TIAM2 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with TIAM2 and Brain
 Blood Antibodies  >1 publications with TIAM2 and Blood
 Embryonic Tissue Antibodies  >1 publications with TIAM2 and Embryonic Tissue
 Testis Antibodies  >1 publications with TIAM2 and Testis
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