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TARDBP elisa kit :: Human TAR DNA binding protein ELISA Kit

Scan QR to view Datasheet Catalog #    MBS705899
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TAR DNA binding protein (TARDBP), ELISA Kit

★Popular Item★
 Also Known As   

Human TAR DNA-binding protein 43, TARDBP/TDP43 ELISA Kit

 Product Synonym Names    Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA kit; RP4-635E18.2; ALS10; TDP-43; TAR DNA-binding protein-43; TAR DNA binding protein
 Product Gene Name   

TARDBP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS705899 Testing Data    Testing Data PDF
 OMIM    gene 612069
 3D Structure    ModBase 3D Structure for Q13148
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human TARDBP. No significant cross-reactivity or interference between human TARDBP and analogues was observed.
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 Samples    Serum, plasma, cell culture supernates, cerebrospinal fluid (CSF).
 Assay Type    Sandwich (Quantitative)
 Detection Range    0.312 ng/ml-20 ng/ml.
 Sensitivity    0.078 ng/ml.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TARDBP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TARDBP purchase    MBS705899 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the TAR DNA binding protein (TARDBP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.312 ng/ml-20 ng/ml in biological research samples containing TARDBP, with an estimated sensitivity of 0.078 ng/ml. The ELISA analytical biochemical technique of the MBS705899 kit is based on TARDBP antibody-TARDBP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TARDBP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TARDBP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, cell culture supernates, cerebrospinal fluid (CSF). Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TARDBP elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for TARDBP has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any TARDBP present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TARDBP is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TARDBP bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of TARDBP elisa kit    TARDBP elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS705899. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TARDBP. It may not necessarily be applicable to this product.
 NCBI GI #    6678271
 NCBI GeneID    23435
 NCBI Accession #    NP_031401.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007375.3 [Other Products]
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 UniProt Primary Accession #    Q13148 [Other Products]
 UniProt Secondary Accession #    Q53H27; Q6FI92; Q96DJ0; A4GUK4; A4GUK5; A4GUK6; B2R629; E2PU12 [Other Products]
 UniProt Related Accession #    Q13148 [Other Products]
 Molecular Weight    44,740 Da
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 NCBI Official Full Name    TAR DNA-binding protein 43
 NCBI Official Synonym Full Names    TAR DNA binding protein
 NCBI Official Symbol    TARDBP [Similar Products]
 NCBI Official Synonym Symbols   
ALS10; TDP-43
[Similar Products]
 NCBI Protein Information    TAR DNA-binding protein 43; TAR DNA-binding protein-43
 UniProt Protein Name    TAR DNA-binding protein 43
 Protein Family    TAR DNA-binding protein
 UniProt Gene Name    TARDBP [Similar Products]
 UniProt Synonym Gene Names    TDP43; TDP-43 [Similar Products]
 UniProt Entry Name    TADBP_HUMAN
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 NCBI Summary for TARDBP    HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TARDBP    Function: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.2 PublicationsManual assertion based on experiment in:Ref.2
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 Research Articles on TARDBP    1. It describes in the present paper on TDP-43 RNA binding, self-regulation and aggregation processes, and attempt to relate them to the neurodegenerative pathologies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TARDBP elisa kitPathways associated with TARDBP elisa kit
 Reference Product  PubMed Publications
 FUS elisa kit  >85 publications with TARDBP and FUS
 SOD1 elisa kit  >76 publications with TARDBP and SOD1
 VCP elisa kit  >26 publications with TARDBP and VCP
 SQSTM1 elisa kit  >6 publications with TARDBP and SQSTM1
 ATXN2 elisa kit  >6 publications with TARDBP and ATXN2
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
Diseases associated with TARDBP elisa kitOrgans/Tissues associated with TARDBP elisa kit
 Disease Name  Pubmed Publications
 Amyotrophic Lateral Sclerosis Antibodies  >185 publications with TARDBP and Amyotrophic Lateral Sclerosis
 Nervous System Diseases Antibodies  >178 publications with TARDBP and Nervous System Diseases
 Brain Diseases Antibodies  >76 publications with TARDBP and Brain Diseases
 Amyotrophic Lateral Sclerosis 10 Antibodies  >36 publications with TARDBP and Amyotrophic Lateral Sclerosis 10
 Disease Models, Animal Antibodies  >16 publications with TARDBP and Disease Models, Animal
 Paralysis Antibodies  >9 publications with TARDBP and Paralysis
 Nerve Degeneration Antibodies  >8 publications with TARDBP and Nerve Degeneration
 Cognition Disorders Antibodies  >5 publications with TARDBP and Cognition Disorders
 Abnormalities, Multiple Antibodies  >4 publications with TARDBP and Abnormalities, Multiple
 Fibrosis Antibodies  >2 publications with TARDBP and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >26 publications with TARDBP and Brain
 Muscle Antibodies  >12 publications with TARDBP and Muscle
 Nerve Antibodies  >6 publications with TARDBP and Nerve
 Blood Antibodies  >5 publications with TARDBP and Blood
 Embryonic Tissue Antibodies  >5 publications with TARDBP and Embryonic Tissue
 Testis Antibodies  >2 publications with TARDBP and Testis
 Bone Antibodies  >1 publications with TARDBP and Bone
 Connective Tissue Antibodies  >1 publications with TARDBP and Connective Tissue
 Heart Antibodies  >1 publications with TARDBP and Heart
 Prostate Antibodies  >1 publications with TARDBP and Prostate
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