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TERF2IP elisa kit :: Human TERF2IP ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2503845
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TERF2IP, ELISA Kit

★Popular Item★
 Also Known As   

Human TERF2IP (Telomeric Repeat Binding Factor 2 Interacting Protein) ELISA Kit

 Product Gene Name   

TERF2IP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    605061
 3D Structure    ModBase 3D Structure for Q9NYB0
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant Human TERF2IP. No significant cross-reactivity or interference between Human TERF2IP and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    1.563-100ng/mL
 Sensitivity    Min: 0.938ng/mL; Max: 100ng/mL
 Intended Uses    This ELISA kit applies to the in vitro quantitative determination of Human TERF2IP concentrations in serum, plasma and other biological fluids.
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TERF2IP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TERF2IP purchase    MBS2503845 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the TERF2IP, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.563-100ng/mL in biological research samples containing TERF2IP, with an estimated sensitivity of Min: 0.938ng/mL; Max: 100ng/mL. The ELISA analytical biochemical technique of the MBS2503845 kit is based on TERF2IP antibody-TERF2IP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TERF2IP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TERF2IP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TERF2IP elisa kit

   Principle of the assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to TERF2IP. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for TERF2IP and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain TERF2IP, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of TERF2IP. You can calculate the concentration of TERF2IP in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of TERF2IP elisa kit    TERF2IP elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2503845. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TERF2IP. It may not necessarily be applicable to this product.
 NCBI GI #    52627149
 NCBI GeneID    54386
 NCBI Accession #    NP_061848.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_018975.3 [Other Products]
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 UniProt Primary Accession #    Q9NYB0 [Other Products]
 UniProt Secondary Accession #    Q4W4Y2; Q8WYZ3; Q9NWR2; B4DQN4 [Other Products]
 UniProt Related Accession #    Q9NYB0 [Other Products]
 Molecular Weight    44,260 Da
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 NCBI Official Full Name    telomeric repeat-binding factor 2-interacting protein 1
 NCBI Official Synonym Full Names    telomeric repeat binding factor 2, interacting protein
 NCBI Official Symbol    TERF2IP [Similar Products]
 NCBI Official Synonym Symbols   
RAP1; DRIP5
[Similar Products]
 NCBI Protein Information    telomeric repeat-binding factor 2-interacting protein 1; RAP1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric RAP1 protein; TRF2-interacting telomeric protein 1; dopamine receptor interacting protein 5; dopamine receptor-interacting protein 5; hRap1; repressor/activator protein 1 homolog
 UniProt Protein Name    Telomeric repeat-binding factor 2-interacting protein 1
 UniProt Synonym Protein Names   
Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homolog; RAP1 homolog; hRap1
 Protein Family    Telomeric repeat-binding factor 2-interacting protein
 UniProt Gene Name    TERF2IP [Similar Products]
 UniProt Synonym Gene Names    DRIP5; RAP1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; RAP1 homolog; hRap1 [Similar Products]
 UniProt Entry Name    TE2IP_HUMAN
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 NCBI Summary for TERF2IP    The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]
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 UniProt Comments for TERF2IP    TERF2IP: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG. Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Interacts with SLX4/BTBD12. Ubiquitous. Highly expressed. Belongs to the RAP1 family.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 16q23.1

Cellular Component: nucleoplasm; nuclear chromosome; chromosome, telomeric region; nuclear telomere cap complex; Mre11 complex; nuclear chromosome, telomeric region; cytoplasm; nuclear envelope; nucleus

Molecular Function: protein binding; telomeric DNA binding

Biological Process: negative regulation of telomere maintenance; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of DNA recombination at telomere; telomere maintenance via telomerase; telomere maintenance; positive regulation of peptidyl-serine phosphorylation; activation of NF-kappaB transcription factor; protection from non-homologous end joining at telomere
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 Research Articles on TERF2IP    1. results indicate that Rap1 miRNA can effectively enhance sensitivity of HepG2 cell line to 5-FU chemotherapy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TERF2IP elisa kitPathways associated with TERF2IP elisa kit
 Reference Product  PubMed Publications
 TERF2 elisa kit  >16 publications with TERF2IP and TERF2
 POT1 elisa kit  >12 publications with TERF2IP and POT1
 TINF2 elisa kit  >9 publications with TERF2IP and TINF2
 ACD elisa kit  >6 publications with TERF2IP and ACD
 SUN1 elisa kit  >2 publications with TERF2IP and SUN1
 RAD50 elisa kit  >1 publications with TERF2IP and RAD50
 MRE11A elisa kit  >1 publications with TERF2IP and MRE11A
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 DNA Damage/Telomere Stress Induced Senescence Pathway antibodies  DNA Damage/Telomere Stress Induced Senescence Pathway Diagram
 Hypothetical Network For Drug Addiction Pathway antibodies  Hypothetical Network For Drug Addiction Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Synapsis Pathway antibodies  Meiotic Synapsis Pathway Diagram
 Packaging Of Telomere Ends Pathway antibodies  Packaging Of Telomere Ends Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
Diseases associated with TERF2IP elisa kitOrgans/Tissues associated with TERF2IP elisa kit
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >5 publications with TERF2IP and Breast Neoplasms
 Adenocarcinoma Antibodies  >5 publications with TERF2IP and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >3 publications with TERF2IP and Cell Transformation, Neoplastic
 Necrosis Antibodies  >3 publications with TERF2IP and Necrosis
 Lung Neoplasms Antibodies  >2 publications with TERF2IP and Lung Neoplasms
 Inflammation Antibodies  >2 publications with TERF2IP and Inflammation
 Liver Neoplasms Antibodies  >2 publications with TERF2IP and Liver Neoplasms
 Metaplasia Antibodies  >2 publications with TERF2IP and Metaplasia
 Cardiovascular Diseases Antibodies  >2 publications with TERF2IP and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1 publications with TERF2IP and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >21 publications with TERF2IP and Blood
 Vascular Antibodies  >10 publications with TERF2IP and Vascular
 Heart Antibodies  >5 publications with TERF2IP and Heart
 Liver Antibodies  >5 publications with TERF2IP and Liver
 Bone Marrow Antibodies  >4 publications with TERF2IP and Bone Marrow
 Bone Antibodies  >4 publications with TERF2IP and Bone
 Skin Antibodies  >4 publications with TERF2IP and Skin
 Brain Antibodies  >4 publications with TERF2IP and Brain
 Thyroid Antibodies  >3 publications with TERF2IP and Thyroid
 Lymph Antibodies  >3 publications with TERF2IP and Lymph
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