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TNFRSF14 elisa kit :: Human TNFRSF14/HVEM ELISA Kit

Scan QR to view Datasheet Catalog #    MBS177345
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
96-Strip-Wells  /  $425 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TNFRSF14/HVEM, ELISA Kit

 Also Known As   

Human TNFRSF14/HVEM PicoKine ELISA Kit

 Product Synonym Names    Protein Tnfrsf14; tumor necrosis factor receptor superfamily, member 14; CD270; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; TNFRSF14; TNR14_HUMAN; TR2; Tumor necrosis factor receptor superfamily member 14; Tumor necrosis factor receptor-like 2
 Product Gene Name   

TNFRSF14 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    602746
 3D Structure    ModBase 3D Structure for Q92956
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 Species Reactivity    Human
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 Specificity    Natural and recombinant human TNFRSF14
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 Samples    Cell culture supernates, serum and plasma (heparin, EDTA)
 Assay Type    Sandwich
 Detection Range    15.6pg/ml-1000pg/ml
 Sensitivity    < 1pg/ml
 Intra-assay Precision    Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision.
 Inter-assay Precision    Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
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 Preparation and Storage    Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TNFRSF14 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TNFRSF14 purchase    MBS177345 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the TNFRSF14/HVEM, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.6pg/ml-1000pg/ml in biological research samples containing TNFRSF14, with an estimated sensitivity of < 1pg/ml. The ELISA analytical biochemical technique of the MBS177345 kit is based on TNFRSF14 antibody-TNFRSF14 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TNFRSF14 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TNFRSF14. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Cell culture supernates, serum and plasma (heparin, EDTA). Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TNFRSF14 elisa kit

   Principle of the assay: human TNFRSF14 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from mouse specific for TNFRSF14 has been precoated onto 96-well plates. Standards(NSO, L39-V202) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for TNFRSF14 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the human TNFRSF14 amount of sample captured in plate.
Background: Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as HVEM, is a protein that in humans is encoded by the TNFRSF14 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. It is mapped to 1p36.32. HVEM plays an important role in HSV pathogenesis because it enhanced the entry of several wildtype HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T cells. HVEM and BTLA which are form a bidirectional signaling pathway can regulate cell survival and inhibitory responses between interacting cells. HVEM as an important orchestrator of mucosal immunity integrates signals from innate lymphocytes to induce optimal epithelial Stat3 activation, which indicated that targeting HVEM with agonists could improve host defense.
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 Typical Testing Data/Standard Curve (for reference only) of TNFRSF14 elisa kit    Human TNFRSF14/HVEM PicoKine ELISA Kit standard curve
TNFRSF14 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS177345. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TNFRSF14. It may not necessarily be applicable to this product.
 NCBI GI #    13878821
 NCBI GeneID    8764
 NCBI Accession #    Q92956.3 [Other Products]
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 UniProt Primary Accession #    Q92956 [Other Products]
 UniProt Secondary Accession #    Q6IB95; Q8N634; Q8WXR1; Q96J31; Q9UM65; B3KW30; B9DI89 [Other Products]
 UniProt Related Accession #    Q92956 [Other Products]
 Molecular Weight    21,351 Da
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 NCBI Official Full Name    Tumor necrosis factor receptor superfamily member 14
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 14
 NCBI Official Symbol    TNFRSF14 [Similar Products]
 NCBI Official Synonym Symbols   
TR2; ATAR; HVEA; HVEM; CD270; LIGHTR
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 14; CD40-like protein; herpes virus entry mediator A; tumor necrosis factor receptor-like gene2; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 14
 UniProt Synonym Protein Names   
Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD_antigen: CD270
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF14 [Similar Products]
 UniProt Synonym Gene Names    HVEA; HVEM; Herpesvirus entry mediator A; HveA; TR2 [Similar Products]
 UniProt Entry Name    TNR14_HUMAN
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 NCBI Summary for TNFRSF14    This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for TNFRSF14    TNFRSF14: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

Protein type: Membrane protein, integral; Cell cycle regulation; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36.32

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: viral receptor activity; protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; entry of virus into host cell; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; T cell costimulation; positive regulation of cytokine secretion during immune response; negative regulation of alpha-beta T cell proliferation; immune response; defense response to Gram-negative bacterium
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 Research Articles on TNFRSF14    1. Sequencing of TNFRSF14 located in the minimal region of loss in 1p36.32 showed nine mutations in pediatric follicular lymphoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNFRSF14 elisa kitPathways associated with TNFRSF14 elisa kit
 Reference Product  PubMed Publications
 BTLA elisa kit  >71 publications with TNFRSF14 and BTLA
 TNFSF14 elisa kit  >66 publications with TNFRSF14 and TNFSF14
 TRAF2 elisa kit  >4 publications with TNFRSF14 and TRAF2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with TNFRSF14 elisa kitOrgans/Tissues associated with TNFRSF14 elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >277 publications with TNFRSF14 and Necrosis
 Inflammation Antibodies  >38 publications with TNFRSF14 and Inflammation
 Arthritis, Rheumatoid Antibodies  >20 publications with TNFRSF14 and Arthritis, Rheumatoid
 Nervous System Diseases Antibodies  >9 publications with TNFRSF14 and Nervous System Diseases
 Liver Diseases Antibodies  >8 publications with TNFRSF14 and Liver Diseases
 Carcinoma Antibodies  >8 publications with TNFRSF14 and Carcinoma
 Neoplasms, Experimental Antibodies  >6 publications with TNFRSF14 and Neoplasms, Experimental
 Anemia Antibodies  >5 publications with TNFRSF14 and Anemia
 Kidney Diseases Antibodies  >2 publications with TNFRSF14 and Kidney Diseases
 Carcinoma, Squamous Cell Antibodies  >2 publications with TNFRSF14 and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >143 publications with TNFRSF14 and Blood
 Bone Antibodies  >14 publications with TNFRSF14 and Bone
 Intestine Antibodies  >11 publications with TNFRSF14 and Intestine
 Eye Antibodies  >11 publications with TNFRSF14 and Eye
 Spleen Antibodies  >10 publications with TNFRSF14 and Spleen
 Liver Antibodies  >10 publications with TNFRSF14 and Liver
 Lymph Node Antibodies  >10 publications with TNFRSF14 and Lymph Node
 Lymph Antibodies  >9 publications with TNFRSF14 and Lymph
 Muscle Antibodies  >7 publications with TNFRSF14 and Muscle
 Ovary Antibodies  >7 publications with TNFRSF14 and Ovary
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