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TNFRSF17 elisa kit :: Human TNFRSF17/BCMA ELISA Kit

Scan QR to view Datasheet Catalog #    MBS177340
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
96-Strip-Wells  /  $425 +1 FREE 8GB USB
 
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 Product Name   

TNFRSF17/BCMA, ELISA Kit

 Also Known As   

Human TNFRSF17/BCMA PicoKine ELISA Kit

 Product Synonym Names    Tumor necrosis factor receptor superfamily member 17; tumor necrosis factor receptor superfamily, member 17; B cell maturation antigen; B cell maturation factor; B cell maturation protein; B-cell maturation protein; BCM; BCMA; CD 269; CD269; CD269 antigen; TNFRSF 17; TNFRSF17; TNR17_HUMAN; Tumor necrosis factor receptor member 17; Tumor necrosis factor receptor superfamily member 17
 Product Gene Name   

TNFRSF17 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    109545
 3D Structure    ModBase 3D Structure for Q02223
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 Species Reactivity    Human
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 Specificity    Natural and recombinant human TNFRSF17
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 Samples    Cell culture supernates, serum and plasma (heparin, EDTA)
 Assay Type    Sandwich
 Detection Range    31.2pg/ml-2000pg/ml
 Sensitivity    < 10pg/ml
 Intra-assay Precision    Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision.
 Inter-assay Precision    Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
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 Preparation and Storage    Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TNFRSF17 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TNFRSF17 purchase    MBS177340 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the TNFRSF17/BCMA, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.2pg/ml-2000pg/ml in biological research samples containing TNFRSF17, with an estimated sensitivity of < 10pg/ml. The ELISA analytical biochemical technique of the MBS177340 kit is based on TNFRSF17 antibody-TNFRSF17 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TNFRSF17 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TNFRSF17. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Cell culture supernates, serum and plasma (heparin, EDTA). Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TNFRSF17 elisa kit

   Principle of the assay: human TNFRSF17 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from mouse specific for TNFRSF17 has been precoated onto 96-well plates. Standards(NSO, M1-A54) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for TNFRSF17 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the human TNFRSF17 amount of sample captured in plate.
Background: TNFRSF17 (Tumor necrosis factor receptor superfamily member 17), also called BCMA, is a protein that in humans is encoded by the TNFRSF17 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily and is mapped to 16p13.13. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
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 Typical Testing Data/Standard Curve (for reference only) of TNFRSF17 elisa kit    Human TNFRSF17/BCMA PicoKine ELISA Kit standard curve
TNFRSF17 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS177340. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TNFRSF17. It may not necessarily be applicable to this product.
 NCBI GI #    313104029
 NCBI GeneID    608
 NCBI Accession #    Q02223.2 [Other Products]
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 UniProt Primary Accession #    Q02223 [Other Products]
 UniProt Secondary Accession #    Q2TQ40 [Other Products]
 UniProt Related Accession #    Q02223 [Other Products]
 Molecular Weight    14,843 Da
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 NCBI Official Full Name    Tumor necrosis factor receptor superfamily member 17
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 17
 NCBI Official Symbol    TNFRSF17 [Similar Products]
 NCBI Official Synonym Symbols   
BCM; BCMA; CD269; TNFRSF13A
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 17
 UniProt Synonym Protein Names   
B-cell maturation protein; CD_antigen: CD269
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF17 [Similar Products]
 UniProt Synonym Gene Names    BCM; BCMA [Similar Products]
 UniProt Entry Name    TNR17_HUMAN
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 NCBI Summary for TNFRSF17    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TNFRSF17    TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Protein type: Oncoprotein; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: integral to membrane; plasma membrane; endomembrane system

Molecular Function: receptor activity

Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction
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 Research Articles on TNFRSF17    1. BAFF and APRIL as well as their cognate receptors (BCMA, TACI) correlate with glioma grade. (Meta-analysis)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNFRSF17 elisa kitPathways associated with TNFRSF17 elisa kit
 Reference Product  PubMed Publications
 TNFSF13B elisa kit  >103 publications with TNFRSF17 and TNFSF13B
 CD83 elisa kit  >16 publications with TNFRSF17 and CD83
 POU2AF1 elisa kit  >8 publications with TNFRSF17 and POU2AF1
 TRAF2 elisa kit  >5 publications with TNFRSF17 and TRAF2
 TRAF3 elisa kit  >4 publications with TNFRSF17 and TRAF3
 TRAF5 elisa kit  >2 publications with TNFRSF17 and TRAF5
 TRAF1 elisa kit  >1 publications with TNFRSF17 and TRAF1
 IGJ elisa kit  >1 publications with TNFRSF17 and IGJ
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
Diseases associated with TNFRSF17 elisa kitOrgans/Tissues associated with TNFRSF17 elisa kit
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >499 publications with TNFRSF17 and Immune System Diseases
 Necrosis Antibodies  >199 publications with TNFRSF17 and Necrosis
 Death Antibodies  >58 publications with TNFRSF17 and Death
 Inflammation Antibodies  >57 publications with TNFRSF17 and Inflammation
 Cardiovascular Diseases Antibodies  >52 publications with TNFRSF17 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >46 publications with TNFRSF17 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >33 publications with TNFRSF17 and Nervous System Diseases
 Leukemia, Myeloid Antibodies  >31 publications with TNFRSF17 and Leukemia, Myeloid
 Skin Diseases Antibodies  >18 publications with TNFRSF17 and Skin Diseases
 Liver Diseases Antibodies  >13 publications with TNFRSF17 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >212 publications with TNFRSF17 and Lymph Node
 Pharynx Antibodies  >29 publications with TNFRSF17 and Pharynx
 Connective Tissue Antibodies  >10 publications with TNFRSF17 and Connective Tissue
 Lung Antibodies  >10 publications with TNFRSF17 and Lung
 Testis Antibodies  >3 publications with TNFRSF17 and Testis
 Eye Antibodies  >3 publications with TNFRSF17 and Eye
 Mammary Gland Antibodies  >2 publications with TNFRSF17 and Mammary Gland
 Uncharacterized Tissue Antibodies  >1 publications with TNFRSF17 and Uncharacterized Tissue
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