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TLR-2 elisa kit :: Human Toll Like Receptor 2 (TLR-2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS268902
Typical Standard Curve/Testing Data
Unit / Price
48-Strip-Wells  /  $260 +1 FREE 8GB USB
96-Strip-Wells  /  $405 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
10x96-Strip-Wells  /  $2,880 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Toll Like Receptor 2 (TLR-2), ELISA Kit

★Popular Item★
 Also Known As   

Human Toll Like Receptor 2 (TLR-2) ELISA Kit

 Product Gene Name   

TLR-2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    603028
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 Species Reactivity    Human
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 Specificity    No cross-reaction with other factors.
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 Samples    Serum, plasma or cell culture supernatant
 Assay Type    Quantitative Sandwich
 Detection Range    20 ng/ml-0.312 ng/ml
 Sensitivity    Up to 0.06 ng/ml.
 Intra-assay Precision    <= 8%
 Inter-assay Precision    <= 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TLR-2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TLR-2 purchase    MBS268902 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Toll Like Receptor 2 (TLR-2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 20 ng/ml-0.312 ng/ml in biological research samples containing TLR-2, with an estimated sensitivity of Up to 0.06 ng/ml. The ELISA analytical biochemical technique of the MBS268902 kit is based on TLR-2 antibody-TLR-2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TLR-2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TLR-2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma or cell culture supernatant. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TLR-2 elisa kit

   Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Human TLR-2 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Standard Curve/Testing Data of TLR-2 elisa kit    TLR-2 elisa kit Typical Standard Curve/Testing Data image
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Sample Manual Insert of MBS268902. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TLR-2. It may not necessarily be applicable to this product.
 NCBI GI #    20140434
 NCBI GeneID    7097
 NCBI Accession #    O60603.1 [Other Products]
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 UniProt Secondary Accession #    O15454; Q8NI00; B3Y612; D1CS45; D1CS48; D1CS49 [Other Products]
 UniProt Related Accession #    O60603 [Other Products]
 Molecular Weight    89,838 Da
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 NCBI Official Full Name    Toll-like receptor 2
 NCBI Official Synonym Full Names    toll-like receptor 2
 NCBI Official Symbol    TLR2 [Similar Products]
 NCBI Official Synonym Symbols   
TIL4; CD282
[Similar Products]
 NCBI Protein Information    toll-like receptor 2; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4
 UniProt Protein Name    Toll-like receptor 2
 UniProt Synonym Protein Names   
Toll/interleukin-1 receptor-like protein 4; CD_antigen: CD282
 UniProt Gene Name    TLR2 [Similar Products]
 UniProt Synonym Gene Names    TIL4 [Similar Products]
 UniProt Entry Name    TLR2_HUMAN
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 NCBI Summary for TLR-2    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TLR-2    TLR2: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage- activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3. Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. Belongs to the Toll-like receptor family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell surface; Receptor, misc.; Apoptosis

Chromosomal Location of Human Ortholog: 4q32

Cellular Component: cell surface; cell projection; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; peptidoglycan binding; transmembrane receptor activity; triacylated lipoprotein binding; protein heterodimerization activity; lipopolysaccharide receptor activity; receptor activity; pattern recognition receptor activity; diacylated lipoprotein binding

Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of leukocyte migration; response to toxin; leukotriene metabolic process; positive regulation of NF-kappaB import into nucleus; detection of triacylated bacterial lipoprotein; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; positive regulation of interferon-beta production; positive regulation of oligodendrocyte differentiation; toll-like receptor 4 signaling pathway; negative regulation of interleukin-12 production; detection of diacylated bacterial lipoprotein; cell surface pattern recognition receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; toll-like receptor 2 signaling pathway; defense response to Gram-positive bacterium; myelin formation in the central nervous system; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; response to progesterone stimulus; positive regulation of nitric-oxide synthase biosynthetic process; apoptosis; positive regulation of interleukin-12 production; microglial cell activation; response to molecule of fungal origin; positive regulation of interleukin-18 production; signal transduction; nitric oxide metabolic process; response to insulin stimulus; positive regulation of interleukin-8 production; negative regulation of cell proliferation; lipopolysaccharide-mediated signaling pathway; inflammatory response; positive regulation of Wnt receptor signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of toll-like receptor signaling pathway; induction by symbiont of defense-related host nitric oxide production; MyD88-dependent toll-like receptor signaling pathway; negative regulation of interleukin-17 production; response to hypoxia; toll-like receptor signaling pathway; innate immune response; immune response; chloramphenicol transport; positive regulation of cytokine secretion; positive regulation of inflammatory response

Disease: Leprosy, Susceptibility To, 3; Mycobacterium Tuberculosis, Susceptibility To
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 Research Articles on TLR-2    1. the expression of TLR-2 and TLR-4 was dysregulated in kidneys of patients with AAV. The expression of TLR-4 in glomeruli was associated with severity of renal injury of patients with AAV.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TLR-2 elisa kitPathways associated with TLR-2 elisa kit
 Reference Product  PubMed Publications
 MYD88 elisa kit  >1052 publications with TLR-2 and MYD88
 CD14 elisa kit  >712 publications with TLR-2 and CD14
 TLR1 elisa kit  >591 publications with TLR-2 and TLR1
 TLR6 elisa kit  >443 publications with TLR-2 and TLR6
 IL6 elisa kit  >130 publications with TLR-2 and IL6
 TIRAP elisa kit  >113 publications with TLR-2 and TIRAP
 LY96 elisa kit  >73 publications with TLR-2 and LY96
 IRAK1 elisa kit  >56 publications with TLR-2 and IRAK1
 TOLLIP elisa kit  >33 publications with TLR-2 and TOLLIP
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Beta Defensins Pathway antibodies  Beta Defensins Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with TLR-2 elisa kitOrgans/Tissues associated with TLR-2 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1988 publications with TLR-2 and Inflammation
 Necrosis Antibodies  >1432 publications with TLR-2 and Necrosis
 Disease Models, Animal Antibodies  >483 publications with TLR-2 and Disease Models, Animal
 Respiratory Tract Diseases Antibodies  >429 publications with TLR-2 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >404 publications with TLR-2 and Lung Diseases
 Atherosclerosis Antibodies  >196 publications with TLR-2 and Atherosclerosis
 Liver Diseases Antibodies  >172 publications with TLR-2 and Liver Diseases
 Asthma Antibodies  >141 publications with TLR-2 and Asthma
 Heart Diseases Antibodies  >132 publications with TLR-2 and Heart Diseases
 Fibrosis Antibodies  >108 publications with TLR-2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2456 publications with TLR-2 and Blood
 Lung Antibodies  >559 publications with TLR-2 and Lung
 Bone Marrow Antibodies  >442 publications with TLR-2 and Bone Marrow
 Liver Antibodies  >353 publications with TLR-2 and Liver
 Brain Antibodies  >287 publications with TLR-2 and Brain
 Kidney Antibodies  >264 publications with TLR-2 and Kidney
 Skin Antibodies  >258 publications with TLR-2 and Skin
 Heart Antibodies  >168 publications with TLR-2 and Heart
 Muscle Antibodies  >165 publications with TLR-2 and Muscle
 Mouth Antibodies  >149 publications with TLR-2 and Mouth
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