NP_003259.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
97,834 Da
NCBI Official Full Name
toll-like receptor 5
NCBI Official Synonym Full Names
toll like receptor 5
NCBI Protein Information
toll-like receptor 5
UniProt Protein Name
Toll-like receptor 5
UniProt Synonym Protein Names
Toll/interleukin-1 receptor-like protein 3
UniProt Synonym Gene Names
UniProt Entry Name
TLR5_HUMAN
NCBI Summary for TLR5
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
UniProt Comments for TLR5
TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q41-q42
Cellular Component: integral to membrane; plasma membrane
Molecular Function: interleukin-1 receptor binding; transmembrane receptor activity
Biological Process: defense response to bacterium; inflammatory response; innate immune response; male gonad development; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of nitric oxide biosynthetic process; positive regulation of toll-like receptor signaling pathway; regulation of cytokine secretion; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor signaling pathway
Disease: Legionnaire Disease, Susceptibility To; Melioidosis, Susceptibility To; Systemic Lupus Erythematosus, Susceptibility To, 1
Research Articles on TLR5
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Products associated with TLR5 elisa kit
Pathways associated with TLR5 elisa kit
Diseases associated with TLR5 elisa kit
Organs/Tissues associated with TLR5 elisa kit
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