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TTR elisa kit :: Human Transthyretin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS762549
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $295 +1 FREE 8GB USB
96-Strip-Wells  /  $390 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,015 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transthyretin (TTR), ELISA Kit

 Also Known As   

Human Transthyretin ELISA Kit

 Product Synonym Names    TTR (Transthyretin)/PALB/TBPA/ATTR/Prealbumin/HsT2651/prealbumin; amyloidosis type I/thyroxine-binding prealbumin
 Product Gene Name   

TTR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 MBS762549 COA    COA PDF
 OMIM    105210
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of TTR. No significant cross-reactivity or interference between TTR and analogues was observed.
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 Samples    Serum, plasma and other biological fluids.
 Assay Type    Sandwich ELISA, Double Antibody
 Detection Range    15.625-1000ng/ml
 Sensitivity    9.375ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level TTR were tested 20 times on one plate, respectively. Intra-Assay: CV<8%
 Inter-assay Precision    Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level TTR were tested on 3 different plates, 8 replicates in each plate. CV (%) = SD/meanX100. Inter-Assay: CV<10%
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 Preparation and Storage    Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of TTR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TTR purchase    MBS762549 is a ready-to-use microwell, strip plate Sandwich, Double Antibody ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Transthyretin (TTR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.625-1000ng/ml in biological research samples containing TTR, with an estimated sensitivity of 9.375ng/ml. The ELISA analytical biochemical technique of the MBS762549 kit is based on TTR antibody-TTR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TTR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TTR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for TTR elisa kit

   Principle of the Assay: This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti- TTR antibody was pre-coated onto 96-well plates. And the biotin conjugated anti- TTR antibody was used as detection antibodies. The standards, test samples and biotin conjugated detection antibody were added to the wells subsequently, and wash with wash buffer. HRP-Streptavidin was added and unbound conjugates were washed away with wash buffer. TMB substrates were used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the TTR amount of sample captured in plate. Read the O.D. absorbance at 450nm in a microplate reader, and then the concentration of TTR can be calculated.
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 Typical Testing Data/Standard Curve (for reference only) of TTR elisa kit    TTR elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS762549
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NCBI/Uniprot data below describe general gene information for TTR. It may not necessarily be applicable to this product.
 NCBI GI #    4507725
 NCBI GeneID    7276
 NCBI Accession #    NP_000362.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000371.3 [Other Products]
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 UniProt Secondary Accession #    Q549C7; Q6IB96; Q9UBZ6; Q9UCM9 [Other Products]
 UniProt Related Accession #    P02766 [Other Products]
 Molecular Weight    15,887 Da
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 NCBI Official Full Name    transthyretin
 NCBI Official Synonym Full Names    transthyretin
 NCBI Official Symbol    TTR [Similar Products]
 NCBI Official Synonym Symbols   
CTS; CTS1; PALB; TBPA; HEL111; HsT2651
[Similar Products]
 NCBI Protein Information    transthyretin
 UniProt Protein Name    Transthyretin
 UniProt Synonym Protein Names   
ATTR; Prealbumin; TBPA
 Protein Family    Transthyretin
 UniProt Gene Name    TTR [Similar Products]
 UniProt Synonym Gene Names    PALB [Similar Products]
 UniProt Entry Name    TTHY_HUMAN
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 NCBI Summary for TTR    This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
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 UniProt Comments for TTR    TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: cytoplasm; extracellular region; extracellular space; protein complex

Molecular Function: hormone activity; hormone binding; identical protein binding; protein binding; protein heterodimerization activity

Biological Process: cellular protein metabolic process; extracellular matrix organization and biogenesis; fat-soluble vitamin metabolic process; phototransduction, visible light; retinoid metabolic process; retinol metabolic process; transport; vitamin metabolic process

Disease: Amyloidosis, Hereditary, Transthyretin-related; Carpal Tunnel Syndrome; Hyperthyroxinemia, Dystransthyretinemic
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 Research Articles on TTR    1. the Swedish TTRHis88Arg patients all have a common Swedish founder. Cardiomyopathy with heart failure, as well as carpal tunnel syndrome and spinal stenosis were early signs of disease; but peripheral neuropathy was present in one patient before symptoms of cardiomyopathy so the phenotypical presentation of this mutation is variable.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TTR elisa kitPathways associated with TTR elisa kit
 Reference Product  PubMed Publications
 RBP4 elisa kit  >40 publications with TTR and RBP4
 APP elisa kit  >14 publications with TTR and APP
 APOA1 elisa kit  >9 publications with TTR and APOA1
 IAPP elisa kit  >4 publications with TTR and IAPP
 HNF4A elisa kit  >2 publications with TTR and HNF4A
 APOA4 elisa kit  >2 publications with TTR and APOA4
 GSN elisa kit  >1 publications with TTR and GSN
 CST3 elisa kit  >1 publications with TTR and CST3
 Products by Pathway  Pathway Diagram
 Amyloid Fiber Formation Pathway antibodies  Amyloid Fiber Formation Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
Diseases associated with TTR elisa kitOrgans/Tissues associated with TTR elisa kit
 Disease Name  Pubmed Publications
 Amyloidosis Antibodies  >943 publications with TTR and Amyloidosis
 Nervous System Diseases Antibodies  >724 publications with TTR and Nervous System Diseases
 Amyloidosis, Familial Antibodies  >652 publications with TTR and Amyloidosis, Familial
 Amyloid Neuropathies, Familial Antibodies  >455 publications with TTR and Amyloid Neuropathies, Familial
 Cardiovascular Diseases Antibodies  >286 publications with TTR and Cardiovascular Diseases
 Heart Diseases Antibodies  >245 publications with TTR and Heart Diseases
 Liver Diseases Antibodies  >153 publications with TTR and Liver Diseases
 Liver Neoplasms Antibodies  >84 publications with TTR and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >81 publications with TTR and Carcinoma, Hepatocellular
 Inflammation Antibodies  >80 publications with TTR and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >537 publications with TTR and Liver
 Heart Antibodies  >304 publications with TTR and Heart
 Brain Antibodies  >278 publications with TTR and Brain
 Muscle Antibodies  >135 publications with TTR and Muscle
 Kidney Antibodies  >127 publications with TTR and Kidney
 Eye Antibodies  >100 publications with TTR and Eye
 Lung Antibodies  >68 publications with TTR and Lung
 Skin Antibodies  >53 publications with TTR and Skin
 Embryonic Tissue Antibodies  >33 publications with TTR and Embryonic Tissue
 Pancreas Antibodies  >31 publications with TTR and Pancreas
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