NP_005642.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,872 Da
NCBI Official Full Name
tryptophan 2,3-dioxygenase
NCBI Official Synonym Full Names
tryptophan 2,3-dioxygenase
NCBI Protein Information
tryptophan 2,3-dioxygenase
UniProt Protein Name
Tryptophan 2,3-dioxygenase
UniProt Synonym Protein Names
Tryptamin 2,3-dioxygenase
UniProt Synonym Gene Names
NCBI Summary for TDO2
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
UniProt Comments for TDO2
TDO2: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. Belongs to the tryptophan 2,3-dioxygenase family.
Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.11; Oxidoreductase
Chromosomal Location of Human Ortholog: 4q32.1
Cellular Component: cytosol
Molecular Function: amino acid binding; heme binding; identical protein binding; metal ion binding; oxygen binding; protein binding; tryptophan 2,3-dioxygenase activity
Biological Process: protein homotetramerization; tryptophan catabolic process; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine
Disease: Hypertryptophanemia
Research Articles on TDO2
Precautions
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Products associated with TDO2 elisa kit
Pathways associated with TDO2 elisa kit
Diseases associated with TDO2 elisa kit
Organs/Tissues associated with TDO2 elisa kit
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