NP_003798.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,395 Da
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 14 isoform 1
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 14
NCBI Protein Information
tumor necrosis factor ligand superfamily member 14
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 14
UniProt Synonym Protein Names
Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand
UniProt Synonym Gene Names
UniProt Entry Name
TNF14_HUMAN
NCBI Summary for TNFSF14
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for TNFSF14
TNFSF14: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Inhibitor; Cytokine
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: extracellular space; cytoplasm; integral to membrane; plasma membrane
Molecular Function: protein binding; caspase inhibitor activity; cytokine activity; tumor necrosis factor receptor binding; receptor binding
Biological Process: T cell proliferation; release of cytoplasmic sequestered NF-kappaB; T cell activation; apoptosis; T cell costimulation; immune response; T cell homeostasis; negative regulation of caspase activity; signal transduction; positive regulation of myoblast differentiation
Research Articles on TNFSF14
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Products associated with TNFSF14 elisa kit
Pathways associated with TNFSF14 elisa kit
Diseases associated with TNFSF14 elisa kit
Organs/Tissues associated with TNFSF14 elisa kit
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