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TNFSR-II elisa kit :: Human Tumor Necrosis Factor Soluble Receptor II ELISA Kit

Scan QR to view Datasheet Catalog #    MBS023494 TNFSR-II elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tumor Necrosis Factor Soluble Receptor II (TNFSR-II), ELISA Kit

 Also Known As   

Human Tumor Necrosis Factor Soluble Receptor II ELISA Kit

 Product Gene Name   

TNFSR-II elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    191191
 3D Structure    ModBase 3D Structure for P20333
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
 Assay Type    Sandwich
 Detection Range    0.25ng/ml-8ng/ml.
 Sensitivity    0.1ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TNFSR-II elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TNFSR-II purchase    MBS023494 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tumor Necrosis Factor Soluble Receptor II (TNFSR-II) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.25ng/ml-8ng/ml in biological research samples containing TNFSR-II, with an estimated sensitivity of 0.1ng/ml. The ELISA analytical biochemical technique of the MBS023494 kit is based on TNFSR-II antibody-TNFSR-II antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TNFSR-II antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TNFSR-II. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for TNFSR-II elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TNFSR-II (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS023494. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TNFSR-II. It may not necessarily be applicable to this product.
 NCBI GI #    4507577
 NCBI GeneID    7133
 NCBI Accession #    NP_001057.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001066.2 [Other Products]
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 UniProt Primary Accession #    P20333 [Other Products]
 UniProt Secondary Accession #    Q16042; Q6YI29; Q9UIH1; B1AJZ3 [Other Products]
 UniProt Related Accession #    P20333 [Other Products]
 Molecular Weight    48,291 Da
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 1B
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 1B
 NCBI Official Symbol    TNFRSF1B [Similar Products]
 NCBI Official Synonym Symbols   
p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis factor receptor 2; tumor necrosis factor beta receptor; tumor necrosis factor receptor type II; tumor necrosis factor binding protein 2
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 1B
 UniProt Synonym Protein Names   
Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD_antigen: CD120b; INN: EtanerceptCleaved into the following 2 chains:Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2Alternative name(s):TBP-2; TBPII
 UniProt Gene Name    TNFRSF1B [Similar Products]
 UniProt Synonym Gene Names    TNFBR; TNFR2; TNF-R2; TNF-RII; TNFR-II [Similar Products]
 UniProt Entry Name    TNR1B_HUMAN
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 NCBI Summary for TNFSR-II    The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TNFSR-II    TNF-R2: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: cell soma; perinuclear region of cytoplasm; plasma membrane; extracellular region; integral to membrane; nucleus; lipid raft

Molecular Function: protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; tumor necrosis factor-mediated signaling pathway; negative regulation of inflammatory response; immune response; inflammatory response; RNA destabilization; positive regulation of membrane protein ectodomain proteolysis; aging
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 Research Articles on TNFSR-II    1. Our findings from two independent community-based cohorts confirm and extend results of previous studies supporting circulating sTNFRs as relevant biomarkers for kidney damage and dysfunction in elderly individuals, even in the absence of diabetes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNFSR-II elisa kitPathways associated with TNFSR-II elisa kit
 Reference Product  PubMed Publications
 TNF elisa kit  >93 publications with TNFSR-II and TNF
 TRAF2 elisa kit  >4 publications with TNFSR-II and TRAF2
 TRAF1 elisa kit  >3 publications with TNFSR-II and TRAF1
 TRADD elisa kit  >2 publications with TNFSR-II and TRADD
 BIRC3 elisa kit  >2 publications with TNFSR-II and BIRC3
 BIRC2 elisa kit  >1 publications with TNFSR-II and BIRC2
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
Diseases associated with TNFSR-II elisa kitOrgans/Tissues associated with TNFSR-II elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >122 publications with TNFSR-II and Necrosis
 Inflammation Antibodies  >35 publications with TNFSR-II and Inflammation
 Neoplasms Antibodies  >18 publications with TNFSR-II and Neoplasms
 Cardiovascular Diseases Antibodies  >15 publications with TNFSR-II and Cardiovascular Diseases
 Lung Diseases Antibodies  >11 publications with TNFSR-II and Lung Diseases
 Heart Diseases Antibodies  >10 publications with TNFSR-II and Heart Diseases
 Obesity Antibodies  >9 publications with TNFSR-II and Obesity
 Carcinoma Antibodies  >9 publications with TNFSR-II and Carcinoma
 Nervous System Diseases Antibodies  >8 publications with TNFSR-II and Nervous System Diseases
 Hypertension Antibodies  >8 publications with TNFSR-II and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >61 publications with TNFSR-II and Blood
 Bone Antibodies  >14 publications with TNFSR-II and Bone
 Heart Antibodies  >12 publications with TNFSR-II and Heart
 Lung Antibodies  >8 publications with TNFSR-II and Lung
 Kidney Antibodies  >7 publications with TNFSR-II and Kidney
 Muscle Antibodies  >7 publications with TNFSR-II and Muscle
 Vascular Antibodies  >7 publications with TNFSR-II and Vascular
 Skin Antibodies  >5 publications with TNFSR-II and Skin
 Nerve Antibodies  >4 publications with TNFSR-II and Nerve
 Connective Tissue Antibodies  >4 publications with TNFSR-II and Connective Tissue
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