NP_009046.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,203 Da
NCBI Official Full Name
tumor necrosis factor-inducible gene 6 protein
NCBI Official Synonym Full Names
TNF alpha induced protein 6
NCBI Official Synonym Symbols
NCBI Protein Information
tumor necrosis factor-inducible gene 6 protein
UniProt Protein Name
Tumor necrosis factor-inducible gene 6 protein
UniProt Synonym Protein Names
Hyaluronate-binding protein; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; TNF alpha-induced protein 6
UniProt Synonym Gene Names
UniProt Entry Name
TSG6_HUMAN
NCBI Summary for TNFAIP6
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
UniProt Comments for TNFAIP6
TNFAIP6: Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
Chromosomal Location of Human Ortholog: 2q23.3
Molecular Function: hyaluronic acid binding
Biological Process: cell adhesion; cell-cell signaling; inflammatory response; negative regulation of inflammatory response; signal transduction
Research Articles on TNFAIP6
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Products associated with TNFAIP6 elisa kit
Diseases associated with TNFAIP6 elisa kit
Organs/Tissues associated with TNFAIP6 elisa kit
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