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CII elisa kit :: Human Type II Collagen Autoantibody ELISA Kit

Scan QR to view Datasheet Catalog #    MBS032528 CII elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Type II Collagen Autoantibody (CII), ELISA Kit

 Also Known As   

Human Type II Collagen Autoantibody ELISA Kit

 Product Gene Name   

CII elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    131230
 3D Structure    ModBase 3D Structure for P08758
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 Species Reactivity    Human
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CII elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CII purchase    MBS032528 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Type II Collagen Autoantibody (CII) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CII. The ELISA analytical biochemical technique of the MBS032528 kit is based on CII antibody-CII antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CII antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CII. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CII. It may not necessarily be applicable to this product.
 NCBI GI #    4502107
 NCBI GeneID    308
 NCBI Accession #    NP_001145.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001154.3 [Other Products]
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 UniProt Primary Accession #    P08758 [Other Products]
 UniProt Secondary Accession #    Q6FHB3; Q6FI16; Q8WV69; Q9UDH9; D3DNW7 [Other Products]
 UniProt Related Accession #    P08758 [Other Products]
 Molecular Weight    35,937 Da
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 NCBI Official Full Name    annexin A5
 NCBI Official Synonym Full Names    annexin A5
 NCBI Official Symbol    ANXA5 [Similar Products]
 NCBI Official Synonym Symbols   
PP4; ANX5; ENX2; RPRGL3; HEL-S-7
[Similar Products]
 NCBI Protein Information    annexin A5; CBP-I; PAP-I; VAC-alpha; annexin V; annexin-5; anchorin CII; endonexin II; lipocortin V; calphobindin I; thromboplastin inhibitor; vascular anticoagulant-alpha; epididymis secretory protein Li 7; placental anticoagulant protein 4; placental anticoagulant protein I
 UniProt Protein Name    Annexin A5
 UniProt Synonym Protein Names   
Anchorin CII; Annexin V; Annexin-5; Calphobindin I; CBP-I; Endonexin II; Lipocortin V; Placental anticoagulant protein 4; PP4; Placental anticoagulant protein I; PAP-I; Thromboplastin inhibitor; Vascular anticoagulant-alpha
 Protein Family    Transcriptional activator
 UniProt Gene Name    ANXA5 [Similar Products]
 UniProt Synonym Gene Names    ANX5; ENX2; PP4; CBP-I; PP4; PAP-I; VAC-alpha [Similar Products]
 UniProt Entry Name    ANXA5_HUMAN
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 NCBI Summary for CII    The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CII    ANXA5: a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Apoptosis; Calcium-binding; Lipid-binding; Inhibitor

Chromosomal Location of Human Ortholog: 4q27

Cellular Component: focal adhesion; membrane; cytoplasm; intracellular; external side of plasma membrane

Molecular Function: phospholipase inhibitor activity; calcium-dependent phospholipid binding; phospholipid binding; calcium ion binding

Biological Process: response to organic substance; negative regulation of catalytic activity; negative regulation of coagulation; blood coagulation; signal transduction; negative regulation of apoptosis

Disease: Pregnancy Loss, Recurrent, Susceptibility To, 3
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 Research Articles on CII    1. This review describes the structure, function and genetic expression of ANXA5, as well as its possible implication in recurrent pregnancy loss.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CII elisa kitPathways associated with CII elisa kit
 Reference Product  PubMed Publications
 CASP3 elisa kit  >616 publications with CII and CASP3
 S100B elisa kit  >3 publications with CII and S100B
 VIM elisa kit  >2 publications with CII and VIM
 PKD1 elisa kit  >1 publications with CII and PKD1
 PRL elisa kit  >1 publications with CII and PRL
 Products by Pathway  Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
Diseases associated with CII elisa kitOrgans/Tissues associated with CII elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >943 publications with CII and Neoplasms
 Necrosis Antibodies  >527 publications with CII and Necrosis
 Cardiovascular Diseases Antibodies  >385 publications with CII and Cardiovascular Diseases
 Inflammation Antibodies  >239 publications with CII and Inflammation
 Heart Diseases Antibodies  >143 publications with CII and Heart Diseases
 Disease Models, Animal Antibodies  >142 publications with CII and Disease Models, Animal
 Lung Diseases Antibodies  >99 publications with CII and Lung Diseases
 Liver Diseases Antibodies  >99 publications with CII and Liver Diseases
 Breast Neoplasms Antibodies  >97 publications with CII and Breast Neoplasms
 Liver Neoplasms Antibodies  >72 publications with CII and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1369 publications with CII and Blood
 Vascular Antibodies  >319 publications with CII and Vascular
 Brain Antibodies  >239 publications with CII and Brain
 Muscle Antibodies  >209 publications with CII and Muscle
 Heart Antibodies  >197 publications with CII and Heart
 Liver Antibodies  >186 publications with CII and Liver
 Lung Antibodies  >177 publications with CII and Lung
 Bone Antibodies  >168 publications with CII and Bone
 Kidney Antibodies  >133 publications with CII and Kidney
 Eye Antibodies  >107 publications with CII and Eye
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