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UCRP elisa kit :: Human UCRP ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2508834
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UCRP, ELISA Kit

★Popular Item★
 Also Known As   

Human UCRP (Ubiquitin Cross Reactive Protein) ELISA Kit

 Product Gene Name   

UCRP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    147571
 3D Structure    ModBase 3D Structure for P05161
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human UCRP. No significant cross-reactivity or interference between Human UCRP and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human UCRP and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    31.25--2000pg/mL
 Sensitivity    18.75pg/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of UCRP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for UCRP purchase    MBS2508834 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the UCRP, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.25--2000pg/mL in biological research samples containing UCRP, with an estimated sensitivity of 18.75pg/mL. The ELISA analytical biochemical technique of the MBS2508834 kit is based on UCRP antibody-UCRP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect UCRP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, UCRP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for UCRP elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of UCRP in human serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human UCRP. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human UCRP and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human UCRP, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human UCRP. You can calculate the concentration of Human UCRP in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of UCRP elisa kit    UCRP elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2508834. Click to request current manual
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NCBI/Uniprot data below describe general gene information for UCRP. It may not necessarily be applicable to this product.
 NCBI GI #    4826774
 NCBI GeneID    9636
 NCBI Accession #    NP_005092.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005101.3 [Other Products]
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 UniProt Primary Accession #    P05161 [Other Products]
 UniProt Secondary Accession #    Q5SVA4; Q7Z2G2; Q96GF0 [Other Products]
 UniProt Related Accession #    P05161 [Other Products]
 Molecular Weight    17,888 Da
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 NCBI Official Full Name    ubiquitin-like protein ISG15
 NCBI Official Synonym Full Names    ISG15 ubiquitin-like modifier
 NCBI Official Symbol    ISG15 [Similar Products]
 NCBI Official Synonym Symbols   
G1P2; IP17; UCRP; IFI15; IMD38; hUCRP
[Similar Products]
 NCBI Protein Information    ubiquitin-like protein ISG15; interferon, alpha-inducible protein (clone IFI-15K); interferon-induced 17-kDa/15-kDa protein; interferon-stimulated protein, 15 kDa; ubiquitin cross-reactive protein
 UniProt Protein Name    Ubiquitin-like protein ISG15
 UniProt Synonym Protein Names   
Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; IP17; Ubiquitin cross-reactive protein; hUCRP
 UniProt Gene Name    ISG15 [Similar Products]
 UniProt Synonym Gene Names    G1P2; UCRP; IP17; hUCRP [Similar Products]
 UniProt Entry Name    ISG15_HUMAN
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 NCBI Summary for UCRP    The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
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 UniProt Comments for UCRP    ISG15: Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Interacts with, and is conjugated to its targets by the UBE1L (E1 enzyme) and UBE2E2 (E2 enzyme) (Probable). Interaction with influenza B NS1 protein inhibits this conjugation. By type I interferons. Detected in lymphoid cells, striated and smooth muscle, several epithelia and neurons.

Protein type: Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: extracellular region; cytosol

Molecular Function: protein binding; protein tag

Biological Process: ISG15-protein conjugation; modification-dependent protein catabolic process; viral reproduction; negative regulation of viral genome replication; regulation of interferon-gamma production; positive regulation of erythrocyte differentiation; cytokine and chemokine mediated signaling pathway; defense response to bacterium; innate immune response; negative regulation of protein ubiquitination; negative regulation of interferon type I production; defense response to virus

Disease: Immunodeficiency 38
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 Research Articles on UCRP    1. intracellular ISG15 is IFN-alpha/beta-inducible not to serve as a substrate for ISGylation-dependent antiviral immunity, but to ensure USP18-dependent regulation of IFN-alpha/beta and prevention of IFN-alpha/beta-dependent autoinflammation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with UCRP elisa kitPathways associated with UCRP elisa kit
 Reference Product  PubMed Publications
 MX1 elisa kit  >45 publications with UCRP and MX1
 IRF7 elisa kit  >27 publications with UCRP and IRF7
 IFIT1 elisa kit  >23 publications with UCRP and IFIT1
 HERC5 elisa kit  >23 publications with UCRP and HERC5
 DDX58 elisa kit  >15 publications with UCRP and DDX58
 IFIT2 elisa kit  >9 publications with UCRP and IFIT2
 IFI6 elisa kit  >8 publications with UCRP and IFI6
 ISG20 elisa kit  >7 publications with UCRP and ISG20
 IFIT3 elisa kit  >7 publications with UCRP and IFIT3
 UBA7 elisa kit  >1 publications with UCRP and UBA7
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies  Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
Diseases associated with UCRP elisa kitOrgans/Tissues associated with UCRP elisa kit
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >45 publications with UCRP and Liver Diseases
 Inflammation Antibodies  >28 publications with UCRP and Inflammation
 Nervous System Diseases Antibodies  >26 publications with UCRP and Nervous System Diseases
 Influenza, Human Antibodies  >26 publications with UCRP and Influenza, Human
 Necrosis Antibodies  >25 publications with UCRP and Necrosis
 Kidney Diseases Antibodies  >16 publications with UCRP and Kidney Diseases
 Disease Models, Animal Antibodies  >14 publications with UCRP and Disease Models, Animal
 Breast Neoplasms Antibodies  >13 publications with UCRP and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >12 publications with UCRP and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >10 publications with UCRP and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >108 publications with UCRP and Blood
 Liver Antibodies  >50 publications with UCRP and Liver
 Kidney Antibodies  >35 publications with UCRP and Kidney
 Lung Antibodies  >32 publications with UCRP and Lung
 Uterus Antibodies  >30 publications with UCRP and Uterus
 Brain Antibodies  >24 publications with UCRP and Brain
 Bone Antibodies  >16 publications with UCRP and Bone
 Placenta Antibodies  >12 publications with UCRP and Placenta
 Skin Antibodies  >9 publications with UCRP and Skin
 Embryonic Tissue Antibodies  >9 publications with UCRP and Embryonic Tissue
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