NP_061949.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,742 Da
NCBI Official Full Name
UDP-glucuronosyltransferase 1-8
NCBI Official Synonym Full Names
UDP glucuronosyltransferase 1 family, polypeptide A8
NCBI Official Synonym Symbols
UDPGT; UGT1H; UGT-1H; UGT1.8; UGT1-08; UGT1A8S; UDPGT 1-8 [Similar Products]
NCBI Protein Information
UDP-glucuronosyltransferase 1-8; UDP-glucuronosyltransferase 1-H; UDP-glucuronosyltransferase 1A8; UDP glycosyltransferase 1 family, polypeptide A8; UDP-glucuronosyltransferase 1 family polypeptide A8s
UniProt Protein Name
UDP-glucuronosyltransferase 1-8
UniProt Synonym Protein Names
UDP-glucuronosyltransferase 1-H; UGT-1H; UGT1H; UDP-glucuronosyltransferase 1A8
UniProt Synonym Gene Names
GNT1; UGT1; UDPGT 1-8; UGT1*8; UGT1-08; UGT1.8; UGT-1H; UGT1H [Similar Products]
UniProt Entry Name
UD18_HUMAN
NCBI Summary for UGT1A8
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]
UniProt Comments for UGT1A8
UGT1A8: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Membrane protein, integral; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Lipid Metabolism - androgen and estrogen; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - pentose and glucuronate interconversions; Xenobiotic Metabolism - drug metabolism - other enzymes; Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.17
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: enzyme inhibitor activity; retinoic acid binding; enzyme binding; protein homodimerization activity; glucuronosyltransferase activity; protein heterodimerization activity; drug binding; fatty acid binding; steroid binding
Biological Process: steroid metabolic process; negative regulation of steroid metabolic process; negative regulation of transferase activity; coumarin metabolic process; flavonoid biosynthetic process; negative regulation of catalytic activity; flavone metabolic process; retinoic acid metabolic process; negative regulation of fatty acid metabolic process; drug metabolic process; fatty acid metabolic process; cellular response to hormone stimulus
Research Articles on UGT1A8
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Pathways associated with UGT1A8 elisa kit
Products by Pathway |
Pathway Diagram |
Ascorbate And Aldarate Metabolism Pathway antibodies |
Ascorbate And Aldarate Metabolism Pathway Diagram |
Ascorbate And Aldarate Metabolism Pathway antibodies |
Ascorbate And Aldarate Metabolism Pathway Diagram |
Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway antibodies |
Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway Diagram |
Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway antibodies |
Ascorbate Biosynthesis, Animals, Glucose-1P => Ascorbate Pathway Diagram |
Biological Oxidations Pathway antibodies |
Biological Oxidations Pathway Diagram |
Drug Metabolism - Cytochrome P450 Pathway antibodies |
Drug Metabolism - Cytochrome P450 Pathway Diagram |
Drug Metabolism - Cytochrome P450 Pathway antibodies |
Drug Metabolism - Cytochrome P450 Pathway Diagram |
Drug Metabolism - Other Enzymes Pathway antibodies |
Drug Metabolism - Other Enzymes Pathway Diagram |
Drug Metabolism - Other Enzymes Pathway antibodies |
Drug Metabolism - Other Enzymes Pathway Diagram |
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies |
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram |
Diseases associated with UGT1A8 elisa kit
Organs/Tissues associated with UGT1A8 elisa kit
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