AAP15166.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,978 Da
NCBI Official Full Name
ULBP4
NCBI Official Synonym Full Names
retinoic acid early transcript 1E
NCBI Official Synonym Symbols
RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7 [Similar Products]
NCBI Protein Information
NKG2D ligand 4; RAE-1-like transcript 4; lymphocyte effector toxicity activation ligand
UniProt Protein Name
NKG2D ligand 4
UniProt Synonym Protein Names
Lymphocyte effector toxicity activation ligand; RAE-1-like transcript 4; RL-4; Retinoic acid early transcript 1E
UniProt Synonym Gene Names
UniProt Entry Name
N2DL4_HUMAN
NCBI Summary for ULBP4
This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
UniProt Comments for ULBP4
RAET1E: Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes. Belongs to the MHC class I family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component: extracellular region; plasma membrane; integral to membrane
Molecular Function: peptide antigen binding; natural killer cell lectin-like receptor binding
Biological Process: regulation of immune response; antigen processing and presentation of peptide antigen via MHC class I; natural killer cell mediated cytotoxicity; T cell mediated cytotoxicity
Research Articles on ULBP4
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Pathways associated with ULBP4 elisa kit
Diseases associated with ULBP4 elisa kit
Organs/Tissues associated with ULBP4 elisa kit
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