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UCHL1 elisa kit :: Human Ubiquitin Carboxyl Terminal Hydrolase L1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS106491 UCHL1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,575 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,055 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1), ELISA Kit

 Also Known As   

Human Ubiquitin Carboxyl Terminal Hydrolase L1 ELISA Kit

 Product Gene Name   

UCHL1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 OMIM    191342
 3D Structure    ModBase 3D Structure for P09936
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples.
 Assay Type    Sandwich
 Detection Range    31.2pg/ml-1000pg/ml.
 Sensitivity    5.0pg/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Other Notes    Small volumes of UCHL1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for UCHL1 purchase    MBS106491 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.2pg/ml-1000pg/ml in biological research samples containing UCHL1, with an estimated sensitivity of 5.0pg/ml. The ELISA analytical biochemical technique of the MBS106491 kit is based on UCHL1 antibody-UCHL1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect UCHL1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, UCHL1. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for UCHL1 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of UCHL1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS106491
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NCBI/Uniprot data below describe general gene information for UCHL1. It may not necessarily be applicable to this product.
 NCBI GI #    21361091
 NCBI GeneID    7345
 NCBI Accession #    NP_004172.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004181.4 [Other Products]
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 UniProt Primary Accession #    P09936 [Other Products]
 UniProt Secondary Accession #    Q4W5K6; Q71UM0 [Other Products]
 UniProt Related Accession #    P09936 [Other Products]
 Molecular Weight    24,824 Da
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 NCBI Official Full Name    ubiquitin carboxyl-terminal hydrolase isozyme L1
 NCBI Official Synonym Full Names    ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
 NCBI Official Symbol    UCHL1 [Similar Products]
 NCBI Official Synonym Symbols   
NDGOA; PARK5; PGP95; PGP9.5; Uch-L1; HEL-117; PGP 9.5
[Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; epididymis luminal protein 117; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase isozyme L1
 UniProt Synonym Protein Names   
Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1
 Protein Family    Ubiquitin carboxyl-terminal hydrolase
 UniProt Gene Name    UCHL1 [Similar Products]
 UniProt Synonym Gene Names    UCH-L1; PGP9.5 [Similar Products]
 UniProt Entry Name    UCHL1_HUMAN
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 NCBI Summary for UCHL1    The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
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 UniProt Comments for UCHL1    UCHL1: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Monomer. Homodimer. Interacts with SNCA. Interacts with COPS5. Found in neuronal cell bodies and processes throughout the neocortex. Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Belongs to the peptidase C12 family.

Protein type: Protease; Ubiquitin conjugating system; Cell development/differentiation; Ligase; EC 3.4.19.12

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; cell soma; axon; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; omega peptidase activity; ubiquitin binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; alpha-2A adrenergic receptor binding; ligase activity

Biological Process: cell proliferation; negative regulation of MAP kinase activity; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; axon target recognition; axon transport of mitochondrion; eating behavior; neuromuscular process; sensory perception of pain; muscle fiber development; adult walking behavior

Disease: Neurodegeneration With Optic Atrophy, Childhood-onset; Parkinson Disease 5, Autosomal Dominant
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 Research Articles on UCHL1    1. Serum levels of UCH-L1 appear to have potential clinical utility in providing valuable information about poisoning severity and outcome after CO poisoning
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with UCHL1 elisa kitPathways associated with UCHL1 elisa kit
 Reference Product  PubMed Publications
 SNCA elisa kit  >26 publications with UCHL1 and SNCA
 APP elisa kit  >7 publications with UCHL1 and APP
 TP53 elisa kit  >3 publications with UCHL1 and TP53
 HSP90AA1 elisa kit  >2 publications with UCHL1 and HSP90AA1
 LAMP2 elisa kit  >1 publications with UCHL1 and LAMP2
 HSPA8 elisa kit  >1 publications with UCHL1 and HSPA8
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Proteasome Degradation Pathway antibodies  Proteasome Degradation Pathway Diagram
Diseases associated with UCHL1 elisa kitOrgans/Tissues associated with UCHL1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >284 publications with UCHL1 and Neoplasms
 Nervous System Diseases Antibodies  >207 publications with UCHL1 and Nervous System Diseases
 Brain Diseases Antibodies  >154 publications with UCHL1 and Brain Diseases
 Movement Disorders Antibodies  >96 publications with UCHL1 and Movement Disorders
 Inflammation Antibodies  >47 publications with UCHL1 and Inflammation
 Disease Models, Animal Antibodies  >35 publications with UCHL1 and Disease Models, Animal
 Adenocarcinoma Antibodies  >32 publications with UCHL1 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >32 publications with UCHL1 and Cardiovascular Diseases
 Peripheral Nervous System Diseases Antibodies  >28 publications with UCHL1 and Peripheral Nervous System Diseases
 Necrosis Antibodies  >21 publications with UCHL1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >193 publications with UCHL1 and Nerve
 Brain Antibodies  >121 publications with UCHL1 and Brain
 Skin Antibodies  >90 publications with UCHL1 and Skin
 Bone Antibodies  >61 publications with UCHL1 and Bone
 Lymph Antibodies  >58 publications with UCHL1 and Lymph
 Lymph Node Antibodies  >57 publications with UCHL1 and Lymph Node
 Vascular Antibodies  >56 publications with UCHL1 and Vascular
 Muscle Antibodies  >55 publications with UCHL1 and Muscle
 Bone Marrow Antibodies  >37 publications with UCHL1 and Bone Marrow
 Lung Antibodies  >37 publications with UCHL1 and Lung
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