Q93050.3
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,600 Da
NCBI Official Full Name
V-type proton ATPase 116 kDa subunit a isoform 1
NCBI Official Synonym Full Names
ATPase, H+ transporting, lysosomal V0 subunit a1
NCBI Official Synonym Symbols
a1; Stv1; VPP1; Vph1; ATP6N1; ATP6N1A [Similar Products]
NCBI Protein Information
V-type proton ATPase 116 kDa subunit a isoform 1; V-ATPase 116 kDa; vacuolar proton pump subunit 1; vacuolar proton pump, subunit 1; vacuolar-type H(+)-ATPase 115 kDa subunit; vacuolar adenosine triphosphatase subunit Ac116; vacuolar proton translocating ATPase 116 kDa subunit A; H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1; clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD); ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD)
UniProt Protein Name
V-type proton ATPase 116 kDa subunit a isoform 1
UniProt Synonym Protein Names
Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
UniProt Synonym Gene Names
UniProt Entry Name
VPP1_HUMAN
NCBI Summary for ATP6V0A1
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP6V0A1
ATP6V0A1: Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle. Belongs to the V-ATPase 116 kDa subunit family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral; Transporter, iron; Transporter, ion channel; Energy Metabolism - oxidative phosphorylation
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: nucleoplasm; Golgi apparatus; phagocytic vesicle membrane; intracellular membrane-bound organelle; cytoplasm; melanosome; integral to membrane; plasma membrane; endosome membrane; vacuolar proton-transporting V-type ATPase complex
Molecular Function: protein binding; hydrogen ion transporting ATPase activity, rotational mechanism; ATPase binding
Biological Process: interaction with host; vacuolar acidification; ATP synthesis coupled proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport
Research Articles on ATP6V0A1
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Organs/Tissues associated with ATP6V0A1 elisa kit
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