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VDR elisa kit :: Human VDR ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2505797
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VDR, ELISA Kit

★Popular Item★
 Also Known As   

Human VDR (Vitamin D Receptor) ELISA Kit

 Product Gene Name   

VDR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    277440
 3D Structure    ModBase 3D Structure for P11473
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human VDR. No significant cross-reactivity or interference between Human VDR and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human VDR and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.625-40ng/mL
 Sensitivity    Min: 0.375ng/mL; Max: 40ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of VDR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for VDR purchase    MBS2505797 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the VDR, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625-40ng/mL in biological research samples containing VDR, with an estimated sensitivity of Min: 0.375ng/mL; Max: 40ng/mL. The ELISA analytical biochemical technique of the MBS2505797 kit is based on VDR antibody-VDR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect VDR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, VDR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for VDR elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of VDR in human serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human VDR. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human VDR and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human VDR, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human VDR. You can calculate the concentration of Human VDR in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of VDR elisa kit    VDR elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2505797. Click to request current manual
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NCBI/Uniprot data below describe general gene information for VDR. It may not necessarily be applicable to this product.
 NCBI GI #    323714265
 NCBI GeneID    7421
 NCBI Accession #    NP_001017536.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001017536.1 [Other Products]
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 UniProt Primary Accession #    P11473 [Other Products]
 UniProt Secondary Accession #    Q5PSV3; B2R5Q1; G3V1V9 [Other Products]
 UniProt Related Accession #    P11473 [Other Products]
 Molecular Weight    53,883 Da
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 NCBI Official Full Name    vitamin D3 receptor isoform VDRB1
 NCBI Official Synonym Full Names    vitamin D (1,25- dihydroxyvitamin D3) receptor
 NCBI Official Symbol    VDR [Similar Products]
 NCBI Official Synonym Symbols   
NR1I1; PPP1R163
[Similar Products]
 NCBI Protein Information    vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; nuclear receptor subfamily 1 group I member 1; protein phosphatase 1, regulatory subunit 163; vitamin D nuclear receptor variant 1
 UniProt Protein Name    Vitamin D3 receptor
 UniProt Synonym Protein Names   
1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
 Protein Family    Vitamin D3 receptor
 UniProt Gene Name    VDR [Similar Products]
 UniProt Synonym Gene Names    NR1I1; VDR [Similar Products]
 UniProt Entry Name    VDR_HUMAN
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 NCBI Summary for VDR    This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]
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 UniProt Comments for VDR    VDR: Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. Defects in VDR are the cause of rickets vitamin D- dependent type 2A (VDDR2A). A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein type: Transcription factor; DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 12q13.11

Cellular Component: nucleoplasm; nucleus; receptor complex

Molecular Function: retinoid X receptor binding; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; vitamin D3 receptor activity; transcription factor activity

Biological Process: lactation; transcription initiation from RNA polymerase II promoter; cell morphogenesis; positive regulation of apoptosis involved in mammary gland involution; negative regulation of transcription from RNA polymerase II promoter; decidualization; signal transduction; intestinal absorption; cellular calcium ion homeostasis; negative regulation of cell proliferation; calcium ion transport; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; negative regulation of transcription, DNA-dependent; skeletal development; positive regulation of keratinocyte differentiation

Disease: Vitamin D-dependent Rickets, Type 2a; Osteoporosis
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 Research Articles on VDR    1. We conclude that Apa I and Bsm I single-nucleotide polymorphisms (SNPs) in the vitamin D receptor gene (VDR) might be associated with susceptibility to CRC among Kashmiris.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with VDR elisa kitPathways associated with VDR elisa kit
 Reference Product  PubMed Publications
 SRC elisa kit  >88 publications with VDR and SRC
 NCOA1 elisa kit  >39 publications with VDR and NCOA1
 MED1 elisa kit  >31 publications with VDR and MED1
 NCOR1 elisa kit  >28 publications with VDR and NCOR1
 NCOA2 elisa kit  >13 publications with VDR and NCOA2
 RXRA elisa kit  >13 publications with VDR and RXRA
 NCOA3 elisa kit  >11 publications with VDR and NCOA3
 CREBBP elisa kit  >6 publications with VDR and CREBBP
 EP300 elisa kit  >4 publications with VDR and EP300
 SNW1 elisa kit  >4 publications with VDR and SNW1
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
Diseases associated with VDR elisa kitOrgans/Tissues associated with VDR elisa kit
 Disease Name  Pubmed Publications
 Osteoporosis Antibodies  >427 publications with VDR and Osteoporosis
 Vitamin D Deficiency Antibodies  >405 publications with VDR and Vitamin D Deficiency
 Kidney Diseases Antibodies  >313 publications with VDR and Kidney Diseases
 Breast Neoplasms Antibodies  >220 publications with VDR and Breast Neoplasms
 Carcinoma Antibodies  >212 publications with VDR and Carcinoma
 Rickets Antibodies  >208 publications with VDR and Rickets
 Inflammation Antibodies  >206 publications with VDR and Inflammation
 Cardiovascular Diseases Antibodies  >178 publications with VDR and Cardiovascular Diseases
 Prostatic Neoplasms Antibodies  >172 publications with VDR and Prostatic Neoplasms
 Hypercalcemia Antibodies  >133 publications with VDR and Hypercalcemia
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1280 publications with VDR and Bone
 Blood Antibodies  >976 publications with VDR and Blood
 Kidney Antibodies  >554 publications with VDR and Kidney
 Parathyroid Antibodies  >409 publications with VDR and Parathyroid
 Skin Antibodies  >313 publications with VDR and Skin
 Intestine Antibodies  >310 publications with VDR and Intestine
 Prostate Antibodies  >261 publications with VDR and Prostate
 Connective Tissue Antibodies  >207 publications with VDR and Connective Tissue
 Muscle Antibodies  >182 publications with VDR and Muscle
 Brain Antibodies  >113 publications with VDR and Brain
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