NP_005420.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,883 Da
NCBI Official Full Name
vascular endothelial growth factor C preproprotein
NCBI Official Synonym Full Names
vascular endothelial growth factor C
NCBI Protein Information
vascular endothelial growth factor C; FLT4 ligand DHM; vascular endothelial growth factor-related protein
UniProt Protein Name
Vascular endothelial growth factor C
UniProt Synonym Protein Names
Flt4 ligand; Flt4-L; Vascular endothelial growth factor-related protein; VRP
UniProt Synonym Gene Names
UniProt Entry Name
VEGFC_HUMAN
NCBI Summary for VEGF-C
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
UniProt Comments for VEGF-C
VEGFC: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Homodimer; non-covalent and antiparallel. Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. Belongs to the PDGF/VEGF growth factor family.
Protein type: Secreted, signal peptide; Secreted; Cell cycle regulation; Motility/polarity/chemotaxis; Cytokine
Chromosomal Location of Human Ortholog: 4q34.3
Cellular Component: extracellular space; membrane; extracellular region
Molecular Function: protein binding; growth factor activity; vascular endothelial growth factor receptor 3 binding; chemoattractant activity
Biological Process: signal transduction; induction of positive chemotaxis; negative regulation of cell proliferation; morphogenesis of embryonic epithelium; platelet degranulation; positive chemotaxis; regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of cell proliferation; angiogenesis; negative regulation of blood pressure; positive regulation of cell-matrix adhesion; response to drug; substrate-bound cell migration; positive regulation of neuroblast proliferation; platelet activation; positive regulation of blood vessel endothelial cell migration; positive regulation of protein amino acid autophosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; organ morphogenesis; positive regulation of angiogenesis; positive regulation of protein secretion; positive regulation of cell division; vascular endothelial growth factor receptor signaling pathway; blood coagulation; positive regulation of epithelial cell proliferation
Disease: Lymphedema, Hereditary, Id
Research Articles on VEGF-C
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Products associated with VEGF-C elisa kit
Pathways associated with VEGF-C elisa kit
Diseases associated with VEGF-C elisa kit
Organs/Tissues associated with VEGF-C elisa kit
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