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VCL elisa kit :: Human Vinculin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS019840 VCL elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vinculin (VCL), ELISA Kit

 Also Known As   

Human Vinculin ELISA Kit

 Product Gene Name   

VCL elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 10; NC_000010.10 (75757872..75879918). Location: 10q22.2
 OMIM    193065
 3D Structure    ModBase 3D Structure for P18206
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 Species Reactivity    Human
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of VCL elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for VCL purchase    MBS019840 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Vinculin (VCL) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing VCL. The ELISA analytical biochemical technique of the MBS019840 kit is based on VCL antibody-VCL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect VCL antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, VCL. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for VCL. It may not necessarily be applicable to this product.
 NCBI GI #    246714
 NCBI GeneID    7414
 NCBI Accession #    AAB21657.1 [Other Products]
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 UniProt Primary Accession #    P18206 [Other Products]
 UniProt Secondary Accession #    Q16450; Q5SWX2; Q7Z3B8; Q8IXU7 [Other Products]
 UniProt Related Accession #    P18206 [Other Products]
 Molecular Weight    123,799 Da
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 NCBI Official Full Name    vinculin
 NCBI Official Synonym Full Names    vinculin
 NCBI Official Symbol    VCL [Similar Products]
 NCBI Official Synonym Symbols   
MV; MVCL; CMD1W; CMH15
[Similar Products]
 NCBI Protein Information    vinculin; metavinculin
 UniProt Protein Name    Vinculin
 UniProt Synonym Protein Names   
Metavinculin
 Protein Family    Vinculin
 UniProt Gene Name    VCL [Similar Products]
 UniProt Synonym Gene Names    MV [Similar Products]
 UniProt Entry Name    VINC_HUMAN
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 NCBI Summary for VCL    Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VCL    Vinculin: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Exhibits self-association properties. Interacts with NRAP and SORBS1. Interacts with TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin. Metavinculin is muscle-specific. Belongs to the vinculin/alpha-catenin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: focal adhesion; costamere; protein complex; extracellular region; intercellular junction; fascia adherens; cytosol; actin cytoskeleton; cell-matrix junction; cell-cell adherens junction; adherens junction; cytoskeleton; plasma membrane; vesicle

Molecular Function: protein binding; cadherin binding; beta-catenin binding; structural molecule activity; actin binding; alpha-catenin binding

Biological Process: lamellipodium biogenesis; platelet activation; platelet degranulation; apical junction assembly; muscle contraction; axon extension; cell-matrix adhesion; morphogenesis of an epithelium; blood coagulation; cell motility; cell adhesion; negative regulation of cell migration

Disease: Cardiomyopathy, Dilated, 1w
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 Research Articles on VCL    1. VAX1 rs10787760, rs6585429 and rs1871345 polymorphisms may be involved in nonsyndromic cleft lip with or without cleft palate in Brazilian patients, but there is no association with polymorphisms in FGF12, VCL, or CX43
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with VCL elisa kitPathways associated with VCL elisa kit
 Reference Product  PubMed Publications
 SRC elisa kit  >6 publications with VCL and SRC
 CTNNB1 elisa kit  >5 publications with VCL and CTNNB1
 PXN elisa kit  >3 publications with VCL and PXN
 TPM1 elisa kit  >2 publications with VCL and TPM1
 CTNNA1 elisa kit  >2 publications with VCL and CTNNA1
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with VCL elisa kitOrgans/Tissues associated with VCL elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >33 publications with VCL and Cardiovascular Diseases
 Neoplasms Antibodies  >26 publications with VCL and Neoplasms
 Drug Toxicity Antibodies  >25 publications with VCL and Drug Toxicity
 Nervous System Diseases Antibodies  >15 publications with VCL and Nervous System Diseases
 Heart Diseases Antibodies  >15 publications with VCL and Heart Diseases
 Brain Diseases Antibodies  >12 publications with VCL and Brain Diseases
 Kidney Diseases Antibodies  >6 publications with VCL and Kidney Diseases
 Neoplasm Metastasis Antibodies  >6 publications with VCL and Neoplasm Metastasis
 Poisoning Antibodies  >5 publications with VCL and Poisoning
 Lung Diseases Antibodies  >4 publications with VCL and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with VCL and Blood
 Muscle Antibodies  >44 publications with VCL and Muscle
 Vascular Antibodies  >20 publications with VCL and Vascular
 Heart Antibodies  >17 publications with VCL and Heart
 Testis Antibodies  >16 publications with VCL and Testis
 Brain Antibodies  >14 publications with VCL and Brain
 Lung Antibodies  >12 publications with VCL and Lung
 Liver Antibodies  >10 publications with VCL and Liver
 Kidney Antibodies  >10 publications with VCL and Kidney
 Bone Antibodies  >8 publications with VCL and Bone
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