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ADAMTS13/vWF cp elisa kit :: Human Von Willebrand Factor cleaving protease ELISA Kit

Scan QR to view Datasheet Catalog #    MBS732179
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells-(Competitive)  /  $470 +1 FREE 8GB USB
48-Strip-Wells-(Sandwich)  /  $470 +1 FREE 8GB USB
96-Strip-Wells-(Competitive)  /  $675 +1 FREE 8GB USB
96-Strip-Wells-(Sandwich)  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells-(Competitive)  /  $2,850 +3 FREE 8GB USB
5x96-Strip-Wells-(Sandwich)  /  $2,850 +3 FREE 8GB USB
10x96-Strip-Wells-(Competitive)  /  $5,340 +6 FREE 8GB USB
10x96-Strip-Wells-(Sandwich)  /  $5,340 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Von Willebrand Factor cleaving protease (ADAMTS13/vWF cp), ELISA Kit

 Also Known As   

Human Von Willebrand Factor cleaving protease ELISA Kit

 Product Gene Name   

ADAMTS13/vWF cp elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    604134
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 Species Reactivity    Human
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 Assay Type    Competitive or Sandwich
 Highest Standards    25ng/mL
 Concentration of Standards    Concentration of Standards
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ADAMTS13/vWF cp elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ADAMTS13/vWF cp purchase    MBS732179 is a ready-to-use microwell, strip plate Competitive or Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Von Willebrand Factor cleaving protease (ADAMTS13/vWF cp) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ADAMTS13/vWF cp. The ELISA analytical biochemical technique of the MBS732179 kit is based on ADAMTS13/vWF cp antibody-ADAMTS13/vWF cp antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAMTS13/vWF cp antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAMTS13/vWF cp. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for ADAMTS13/vWF cp elisa kit    Cardiovascular
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 Typical Testing Data/Standard Curve (for reference only) of ADAMTS13/vWF cp elisa kit    ADAMTS13/vWF cp elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS732179. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ADAMTS13/vWF cp. It may not necessarily be applicable to this product.
 NCBI GI #    73695936
 NCBI GeneID    11093
 NCBI Accession #    NP_620596.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_139027.4 [Other Products]
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 UniProt Secondary Accession #    Q6UY16; Q710F6; Q711T8; Q96L37; Q9H0G3; Q9UGQ1 [Other Products]
 UniProt Related Accession #    Q76LX8 [Other Products]
 Molecular Weight    39,864 Da
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 2 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 13
 NCBI Official Symbol    ADAMTS13 [Similar Products]
 NCBI Official Synonym Symbols   
VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 13; vWF-cleaving protease; von Willebrand factor-cleaving protease; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 13
 UniProt Synonym Protein Names   
von Willebrand factor-cleaving protease; vWF-CP; vWF-cleaving protease
 UniProt Gene Name    ADAMTS13 [Similar Products]
 UniProt Synonym Gene Names    C9orf8; UNQ6102/PRO20085; ADAM-TS 13; ADAM-TS13; ADAMTS-13; vWF-CP; vWF-cleaving protease [Similar Products]
 UniProt Entry Name    ATS13_HUMAN
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 NCBI Summary for ADAMTS13/vWF cp    This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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 UniProt Comments for ADAMTS13/vWF cp    ADAMTS13: Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding; Extracellular matrix; EC 3.4.24.87; Secreted; Protease; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; endoplasmic reticulum lumen

Molecular Function: integrin binding; protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; calcium ion binding

Biological Process: integrin-mediated signaling pathway; protein amino acid O-linked glycosylation; platelet activation; cellular protein metabolic process; glycoprotein metabolic process; cell-matrix adhesion; peptide catabolic process; response to toxin; protein processing; proteolysis; post-translational protein modification

Disease: Thrombotic Thrombocytopenic Purpura, Congenital
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 Research Articles on ADAMTS13/vWF cp    1. This review discusses the available evidence for a role of ADAMTS13 in various disease states and the potential therapeutic benefit of restoration of ADAMTS13 levels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ADAMTS13/vWF cp elisa kitPathways associated with ADAMTS13/vWF cp elisa kit
 Reference Product  PubMed Publications
 VWF elisa kit  >598 publications with ADAMTS13/vWF cp and VWF
 ABO elisa kit  >27 publications with ADAMTS13/vWF cp and ABO
 SERPINC1 elisa kit  >2 publications with ADAMTS13/vWF cp and SERPINC1
 CFHR1 elisa kit  >2 publications with ADAMTS13/vWF cp and CFHR1
 CFHR3 elisa kit  >1 publications with ADAMTS13/vWF cp and CFHR3
 GP1BA elisa kit  >1 publications with ADAMTS13/vWF cp and GP1BA
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies  O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Diseases associated with ADAMTS13/vWF cp elisa kitOrgans/Tissues associated with ADAMTS13/vWF cp elisa kit
 Disease Name  Pubmed Publications
 Purpura, Thrombotic Thrombocytopenic Antibodies  >944 publications with ADAMTS13/vWF cp and Purpura, Thrombotic Thrombocytopenic
 Thrombotic Microangiopathies Antibodies  >872 publications with ADAMTS13/vWF cp and Thrombotic Microangiopathies
 Kidney Diseases Antibodies  >228 publications with ADAMTS13/vWF cp and Kidney Diseases
 Purpura, Thrombocytopenic, Idiopathic Antibodies  >161 publications with ADAMTS13/vWF cp and Purpura, Thrombocytopenic, Idiopathic
 Inflammation Antibodies  >75 publications with ADAMTS13/vWF cp and Inflammation
 Fever Antibodies  >67 publications with ADAMTS13/vWF cp and Fever
 Liver Diseases Antibodies  >44 publications with ADAMTS13/vWF cp and Liver Diseases
 Disease Models, Animal Antibodies  >33 publications with ADAMTS13/vWF cp and Disease Models, Animal
 Necrosis Antibodies  >23 publications with ADAMTS13/vWF cp and Necrosis
 Liver Failure Antibodies  >21 publications with ADAMTS13/vWF cp and Liver Failure
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >943 publications with ADAMTS13/vWF cp and Blood
 Kidney Antibodies  >116 publications with ADAMTS13/vWF cp and Kidney
 Liver Antibodies  >91 publications with ADAMTS13/vWF cp and Liver
 Brain Antibodies  >53 publications with ADAMTS13/vWF cp and Brain
 Connective Tissue Antibodies  >15 publications with ADAMTS13/vWF cp and Connective Tissue
 Nerve Antibodies  >5 publications with ADAMTS13/vWF cp and Nerve
 Ovary Antibodies  >4 publications with ADAMTS13/vWF cp and Ovary
 Intestine Antibodies  >3 publications with ADAMTS13/vWF cp and Intestine
 Placenta Antibodies  >2 publications with ADAMTS13/vWF cp and Placenta
 Eye Antibodies  >1 publications with ADAMTS13/vWF cp and Eye
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