NP_067020.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,977 Da
NCBI Official Full Name
WAP four-disulfide core domain protein 1 isoform 1
NCBI Official Synonym Full Names
WAP four-disulfide core domain 1
NCBI Official Synonym Symbols
NCBI Protein Information
WAP four-disulfide core domain protein 1; ps20 growth inhibitor; prostate stromal protein ps20; WAP four-disulfide core domain 1 homolog
UniProt Protein Name
WAP four-disulfide core domain protein 1
UniProt Synonym Protein Names
Prostate stromal protein ps20; ps20 growth inhibitor
UniProt Synonym Gene Names
UniProt Entry Name
WFDC1_HUMAN
NCBI Summary for WFDC1
This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Comments for WFDC1
WFDC1: Has growth inhibitory activity.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase inhibitor activity
Biological Process: response to drug; negative regulation of cell growth; response to estradiol stimulus; negative regulation of epithelial cell proliferation
Research Articles on WFDC1
Precautions
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Products associated with WFDC1 elisa kit
Diseases associated with WFDC1 elisa kit
Organs/Tissues associated with WFDC1 elisa kit
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