NP_001188333.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,284 Da
NCBI Official Full Name
wiskott-Aldrich syndrome protein family member 2 isoform 2
NCBI Official Synonym Full Names
WAS protein family, member 2
NCBI Official Synonym Symbols
IMD2; SCAR2; WASF4; WAVE2; dJ393P12.2 [Similar Products]
NCBI Protein Information
wiskott-Aldrich syndrome protein family member 2; protein WAVE-2; WASP family protein member 2; WASP family protein member 4; WASP family Verprolin-homologous protein 2; verprolin homology domain-containing protein 2; suppressor of cyclic-AMP receptor (WASP-family); putative Wiskott-Aldrich syndrome protein family member 4
UniProt Protein Name
Wiskott-Aldrich syndrome protein family member 2
UniProt Synonym Protein Names
Protein WAVE-2; Verprolin homology domain-containing protein 2
UniProt Synonym Gene Names
UniProt Entry Name
WASF2_HUMAN
NCBI Summary for WASF2
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for WASF2
WAVE2: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1. Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. Belongs to the SCAR/WAVE family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: ruffle; lamellipodium; early endosome; intracellular; intercellular junction; cytosol; actin cytoskeleton
Molecular Function: protein binding; protein complex binding; actin binding
Biological Process: lamellipodium biogenesis; G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of stress fiber formation; actin filament-based movement; ameboidal cell migration; Rac protein signal transduction; innate immune response; angiogenesis; vascular endothelial growth factor receptor signaling pathway; actin cytoskeleton organization and biogenesis
Research Articles on WASF2
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Products associated with WASF2 elisa kit
Pathways associated with WASF2 elisa kit
Diseases associated with WASF2 elisa kit
Organs/Tissues associated with WASF2 elisa kit
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