AAH08811.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,005 Da
NCBI Official Full Name
Wingless-type MMTV integration site family, member 7A
NCBI Official Synonym Full Names
wingless-type MMTV integration site family, member 7A
NCBI Protein Information
protein Wnt-7a
UniProt Protein Name
Protein Wnt-7a
UniProt Entry Name
WNT7A_HUMAN
NCBI Summary for WNT7A
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]
UniProt Comments for WNT7A
WNT7A: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts. Defects in WNT7A are the cause of limb pelvis hypoplasia aplasia syndrome (LPHAS). A syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present. Defects in WNT7A are a cause of Fuhrmann syndrome (FUHRS); also known as fibular aplasia or hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia. Belongs to the Wnt family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 3p25
Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; endoplasmic reticulum lumen; Golgi lumen; extracellular region; plasma membrane
Molecular Function: frizzled binding; cytokine activity; receptor agonist activity; receptor binding
Biological Process: embryonic forelimb morphogenesis; somatic stem cell maintenance; cell proliferation in forebrain; neurotransmitter secretion; positive regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of JNK cascade; palate development; Wnt receptor signaling pathway through beta-catenin; embryonic hindlimb morphogenesis; response to estradiol stimulus; negative regulation of neurogenesis; neuron differentiation; central nervous system vasculogenesis; synapse organization and biogenesis; regulation of axon diameter; chondrocyte differentiation; somatic stem cell division; satellite cell activation; angiogenesis; fallopian tube development; cartilage condensation; cell fate commitment; embryonic axis specification; satellite cell compartment self-renewal involved in skeletal muscle regeneration; cerebellar granule cell differentiation; asymmetric protein localization; positive regulation of synaptogenesis; stem cell development; dorsal/ventral pattern formation; establishment of cell polarity; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; sex differentiation; negative regulation of apoptosis
Disease: Ulna And Fibula, Absence Of, With Severe Limb Deficiency; Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly
Research Articles on WNT7A
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Products associated with WNT7A elisa kit
Pathways associated with WNT7A elisa kit
Diseases associated with WNT7A elisa kit
Organs/Tissues associated with WNT7A elisa kit
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