NP_004550.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,924 Da
NCBI Official Full Name
nuclease-sensitive element-binding protein 1
NCBI Official Synonym Full Names
Y box binding protein 1
NCBI Official Synonym Symbols
YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1 [Similar Products]
NCBI Protein Information
nuclease-sensitive element-binding protein 1; CBF-A; EFI-A; DNA-binding protein B; Y-box-binding protein 1; Y-box transcription factor; enhancer factor I subunit A; nuclease sensitive element binding protein 1; CCAAT-binding transcription factor I subunit A; major histocompatibility complex, class II, Y box-binding protein I
UniProt Protein Name
Nuclease-sensitive element-binding protein 1
UniProt Synonym Protein Names
CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Y-box transcription factor; Y-box-binding protein 1; YB-1
UniProt Synonym Gene Names
UniProt Entry Name
YBOX1_HUMAN
UniProt Comments for YBX1
YB-1: a nuclear protein that binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors CCAAT-containing Y-box of HLA class II genes. Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Interacts with AKT1, SFRS9, THOC4, MSH2, XRCC5, WRN and NCL. Can bind to DNA as a homomeric form, (EFI-A)n or as a heteromeric form in association with EFI-B. Homodimer in the presence of ATP. Involved in cisplatin resistance. Seems to be a negative regulatory factor. May play a role in both transcriptional and translational regulation of spermatogenesis. Found at very low levels at day 10 and levels increase at day 15 and persist throughout adulthood.
Protein type: RNA processing; Transcription factor; RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: nucleoplasm; nuclear membrane; intracellular membrane-bound organelle; stress granule; cytoplasm; ribonucleoprotein complex; nucleus; U12-dependent spliceosome
Molecular Function: protein binding; DNA binding; RNA binding; double-stranded DNA binding; transcription factor activity; single-stranded DNA binding
Biological Process: nuclear mRNA splicing, via spliceosome; negative regulation of striated muscle cell differentiation; transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; in utero embryonic development; positive regulation of cell division; RNA splicing; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
Research Articles on YBX1
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Products associated with YBX1 elisa kit
Pathways associated with YBX1 elisa kit
Diseases associated with YBX1 elisa kit
Organs/Tissues associated with YBX1 elisa kit
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