NP_056161.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
284,576 Da
NCBI Official Full Name
zinc finger FYVE domain-containing protein 26
NCBI Official Synonym Full Names
zinc finger, FYVE domain containing 26
NCBI Protein Information
zinc finger FYVE domain-containing protein 26; spastizin; FYVE domain-containing centrosomal protein
UniProt Protein Name
Zinc finger FYVE domain-containing protein 26
UniProt Synonym Protein Names
FYVE domain-containing centrosomal protein; FYVE-CENT; Spastizin
UniProt Synonym Gene Names
UniProt Entry Name
ZFY26_HUMAN
NCBI Summary for ZFYVE26
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
UniProt Comments for ZFYVE26
ZFYVE26: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 14q24.1
Cellular Component: centrosome; lysosomal membrane; midbody
Molecular Function: protein binding; metal ion binding; phosphatidylinositol 3-phosphate binding
Biological Process: cytokinesis; double-strand break repair via homologous recombination
Disease: Spastic Paraplegia 15, Autosomal Recessive
Research Articles on ZFYVE26
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Products associated with ZFYVE26 elisa kit
Diseases associated with ZFYVE26 elisa kit
Organs/Tissues associated with ZFYVE26 elisa kit
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