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ABHD12 elisa kit :: Human abhydrolase domain containing 12 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9333436 ABHD12 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

abhydrolase domain containing 12 (ABHD12), ELISA Kit

 Also Known As   

Human Monoacylglycerol lipase ABHD12, ABHD12 ELISA Kit

 Product Synonym Names    Human Monoacylglycerol lipase ABHD12 (ABHD12) ELISA kit; RP5-965G21.2; ABHD12A; BEM46L2; C20orf22; DKFZp434P106; dJ965G21.2; ; abhydrolase domain containing 12
 Product Gene Name   

ABHD12 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    613599
 3D Structure    ModBase 3D Structure for Q8N2K0
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ABHD12 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ABHD12 purchase    MBS9333436 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the abhydrolase domain containing 12 (ABHD12) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ABHD12. The ELISA analytical biochemical technique of the MBS9333436 kit is based on ABHD12 antibody-ABHD12 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ABHD12 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ABHD12. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ABHD12. It may not necessarily be applicable to this product.
 NCBI GI #    109689718
 NCBI GeneID    26090
 NCBI Accession #    NP_001035937.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001042472.2 [Other Products]
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 UniProt Primary Accession #    Q8N2K0 [Other Products]
 UniProt Secondary Accession #    Q5T710; Q5T711; Q96CR1; Q9BX05; Q9NPX7; Q9UFV6; A6NED4; A6NJ90; A8K450; B4DE71 [Other Products]
 UniProt Related Accession #    Q8N2K0 [Other Products]
 Molecular Weight    45,097 Da
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 NCBI Official Full Name    monoacylglycerol lipase ABHD12 isoform a
 NCBI Official Synonym Full Names    abhydrolase domain containing 12
 NCBI Official Symbol    ABHD12 [Similar Products]
 NCBI Official Synonym Symbols   
PHARC; ABHD12A; BEM46L2; C20orf22; dJ965G21.2
[Similar Products]
 NCBI Protein Information    monoacylglycerol lipase ABHD12; 2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 12
 UniProt Protein Name    Monoacylglycerol lipase ABHD12
 UniProt Synonym Protein Names   
2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 12
 Protein Family    Monoacylglycerol lipase
 UniProt Gene Name    ABHD12 [Similar Products]
 UniProt Synonym Gene Names    C20orf22 [Similar Products]
 UniProt Entry Name    ABD12_HUMAN
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 NCBI Summary for ABHD12    This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]
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 UniProt Comments for ABHD12    ABHD12: Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways. Defects in ABHD12 are the cause of polyneuropathy hearing loss ataxia retinitis pigmentosa and cataract (PHARC). PHARC is a slowly progressive neurologic disorder with a variable phenotype resembling Refsum disease. Clinical features include sensorineural hearing loss, visual problems related to cataracts, retinitis pigmentosa, pes cavus, ataxic and/or spastic gait disturbances with a progressive sensorimotor peripheral neuropathy. Other features include hyporeflexia, hyperreflexia, extensor plantar responses. Belongs to the serine esterase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.23; Membrane protein, integral; Hydrolase

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: integral to membrane

Molecular Function: acylglycerol lipase activity

Biological Process: phosphatidylserine catabolic process; adult walking behavior; acylglycerol catabolic process

Disease: Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract
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 Research Articles on ABHD12    1. This is the first report of compound heterozygosity in PHARC and the first study to describe how a mutation might affect ABHD12 expression and function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ABHD12 elisa kitDiseases associated with ABHD12 elisa kit
 Products by Pathway  Pathway Diagram
 Triacylglycerol Degradation Pathway antibodies  Triacylglycerol Degradation Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with ABHD12 and Inflammation
 Disease Models, Animal Antibodies  >2 publications with ABHD12 and Disease Models, Animal
 Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract Antibodies  >2 publications with ABHD12 and Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract
 Demyelinating Diseases Antibodies  >1 publications with ABHD12 and Demyelinating Diseases
 Fatty Liver Antibodies  >1 publications with ABHD12 and Fatty Liver
 Drug-Induced Liver Injury Antibodies  >1 publications with ABHD12 and Drug-Induced Liver Injury
Organs/Tissues associated with ABHD12 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with ABHD12 and Brain
 Liver Antibodies  >1 publications with ABHD12 and Liver
 Blood Antibodies  >1 publications with ABHD12 and Blood
 Eye Antibodies  >1 publications with ABHD12 and Eye
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