NP_004915.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
104,854 Da
NCBI Official Full Name
alpha-actinin-4
NCBI Official Synonym Full Names
actinin, alpha 4
NCBI Protein Information
alpha-actinin-4; actinin alpha4 isoform; non-muscle alpha-actinin 4; F-actin cross-linking protein; focal segmental glomerulosclerosis 1
UniProt Protein Name
Alpha-actinin-4
UniProt Synonym Protein Names
F-actin cross-linking protein; Non-muscle alpha-actinin 4
UniProt Entry Name
ACTN4_HUMAN
NCBI Summary for ACTN4
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
UniProt Comments for ACTN4
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions.
Research Articles on ACTN4
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Products associated with ACTN4 elisa kit
Pathways associated with ACTN4 elisa kit
Diseases associated with ACTN4 elisa kit
Organs/Tissues associated with ACTN4 elisa kit
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