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AICDA elisa kit :: Human activation-induced cytidine deaminase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS940658
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

activation-induced cytidine deaminase (AICDA), ELISA Kit

★Popular Item★
 Also Known As   

Human Activation-induced cytidine deaminase, AICDA ELISA Kit

 Product Synonym Names    Human Activation-induced cytidine deaminase (AICDA) ELISA kit; AID; ARP2; CDA2; HIGM2; integrated into Burkitt s lymphoma cell line Ramos; activation-induced cytidine deaminase
 Product Gene Name   

AICDA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS940658 Testing Data    Testing Data PDF
 OMIM    gene 605258
 3D Structure    ModBase 3D Structure for Q9GZX7
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human AICDA. No significant cross-reactivity or interference between human AICDA and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, cell lysates.
 Assay Type    Sandwich
 Detection Range    34.4 pg/ml -2200 pg/ml.
 Sensitivity    8.6 pg /ml.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of AICDA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AICDA purchase    MBS940658 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the activation-induced cytidine deaminase (AICDA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 34.4 pg/ml -2200 pg/ml in biological research samples containing AICDA, with an estimated sensitivity of 8.6 pg /ml. The ELISA analytical biochemical technique of the MBS940658 kit is based on AICDA antibody-AICDA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AICDA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AICDA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for AICDA elisa kit

   Principle of the Assay||This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for AICDA has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any AICDA present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for AICDA is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of AICDA bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of AICDA elisa kit    AICDA elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS940658. Click to request current manual
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NCBI/Uniprot data below describe general gene information for AICDA. It may not necessarily be applicable to this product.
 NCBI GI #    10190700
 NCBI GeneID    57379
 NCBI Accession #    NP_065712.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020661.2 [Other Products]
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 UniProt Primary Accession #    Q9GZX7 [Other Products]
 UniProt Secondary Accession #    Q6QJ81; Q8NFC1 [Other Products]
 UniProt Related Accession #    Q9GZX7 [Other Products]
 Molecular Weight    23,954 Da
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 NCBI Official Full Name    single-stranded DNA cytosine deaminase
 NCBI Official Synonym Full Names    activation-induced cytidine deaminase
 NCBI Official Symbol    AICDA [Similar Products]
 NCBI Official Synonym Symbols   
AID; ARP2; CDA2; HIGM2; HEL-S-284
[Similar Products]
 NCBI Protein Information    single-stranded DNA cytosine deaminase; cytidine aminohydrolase; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos
 UniProt Protein Name    Single-stranded DNA cytosine deaminase
 UniProt Synonym Protein Names   
Activation-induced cytidine deaminase; Cytidine aminohydrolase
 Protein Family    Single-stranded DNA cytosine deaminase
 UniProt Gene Name    AICDA [Similar Products]
 UniProt Synonym Gene Names    AID [Similar Products]
 UniProt Entry Name    AICDA_HUMAN
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 NCBI Summary for AICDA    This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
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 UniProt Comments for AICDA    AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: Hydrolase; EC 3.5.4.38

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; exosome (RNase complex); nucleus

Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; cytidine deaminase activity

Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; cytidine deamination; mRNA processing

Disease: Immunodeficiency With Hyper-igm, Type 2
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 Research Articles on AICDA    1. findings reveal additional functions for AID in innate immune defense against KSHV with implications for a broader involvement in innate immunity to other pathogens.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AICDA elisa kitPathways associated with AICDA elisa kit
 Reference Product  PubMed Publications
 RPA1 elisa kit  >4 publications with AICDA and RPA1
 Products by Pathway  Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Salvage Pathways Of Pyrimidine Deoxyribonucleotides antibodies  Salvage Pathways Of Pyrimidine Deoxyribonucleotides Diagram
 Salvage Pathways Of Pyrimidine Ribonucleotides antibodies  Salvage Pathways Of Pyrimidine Ribonucleotides Diagram
Diseases associated with AICDA elisa kitOrgans/Tissues associated with AICDA elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >163 publications with AICDA and Neoplasms
 Autoimmune Diseases Antibodies  >25 publications with AICDA and Autoimmune Diseases
 Neoplasms, Experimental Antibodies  >23 publications with AICDA and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >18 publications with AICDA and Disease Models, Animal
 Liver Diseases Antibodies  >15 publications with AICDA and Liver Diseases
 IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 2 Antibodies  >15 publications with AICDA and IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 2
 Skin Diseases Antibodies  >14 publications with AICDA and Skin Diseases
 Adenocarcinoma Antibodies  >10 publications with AICDA and Adenocarcinoma
 Leukemia, Myeloid Antibodies  >7 publications with AICDA and Leukemia, Myeloid
 Nervous System Diseases Antibodies  >6 publications with AICDA and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >359 publications with AICDA and Blood
 Lymph Node Antibodies  >74 publications with AICDA and Lymph Node
 Kidney Antibodies  >23 publications with AICDA and Kidney
 Lymph Antibodies  >19 publications with AICDA and Lymph
 Tonsil Antibodies  >11 publications with AICDA and Tonsil
 Pharynx Antibodies  >7 publications with AICDA and Pharynx
 Pancreas Antibodies  >1 publications with AICDA and Pancreas
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