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ACVR1 elisa kit :: Human activin A receptor, type I ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9323715 ACVR1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

activin A receptor, type I (ACVR1), ELISA Kit

 Also Known As   

Human Activin receptor type-1, ACVR1 ELISA Kit

 Product Synonym Names    Human Activin receptor type-1 (ACVR1) ELISA kit; ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI; OTTHUMP00000204604; OTTHUMP00000204626; TGF-B superfamily receptor type I; activin A receptor; type II-like kinase 2; hydroxyalkyl-protein kinase; serine/th; activin A receptor; type I
 Product Gene Name   

ACVR1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 135100
 3D Structure    ModBase 3D Structure for Q04771
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACVR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ACVR1 purchase    MBS9323715 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the activin A receptor, type I (ACVR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACVR1. The ELISA analytical biochemical technique of the MBS9323715 kit is based on ACVR1 antibody-ACVR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACVR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACVR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ACVR1. It may not necessarily be applicable to this product.
 NCBI GI #    4501895
 NCBI GeneID    90
 NCBI Accession #    NP_001096.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001105.4 [Other Products]
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 UniProt Primary Accession #    Q04771 [Other Products]
 UniProt Related Accession #    Q04771 [Other Products]
 Molecular Weight    57,153 Da
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 NCBI Official Full Name    activin receptor type-1
 NCBI Official Synonym Full Names    activin A receptor, type I
 NCBI Official Symbol    ACVR1 [Similar Products]
 NCBI Official Synonym Symbols   
FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
[Similar Products]
 NCBI Protein Information    activin receptor type-1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1
 UniProt Protein Name    Activin receptor type-1
 UniProt Synonym Protein Names   
Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I
 Protein Family    Activin receptor
 UniProt Gene Name    ACVR1 [Similar Products]
 UniProt Synonym Gene Names    ACVRLK2; ACTR-I; ALK-2; SKR1; TSR-I [Similar Products]
 UniProt Entry Name    ACVR1_HUMAN
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 NCBI Summary for ACVR1    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACVR1    ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Membrane protein, integral; Protein kinase, TKL; Kinase, protein; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 2q23-q24

Cellular Component: apical part of cell; integral to plasma membrane; activin receptor complex

Molecular Function: protein serine/threonine kinase activity; protein binding; protein homodimerization activity; activin receptor activity, type I; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; peptide hormone binding; metal ion binding; activin binding; SMAD binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; neural crest cell migration; pharyngeal system development; in utero embryonic development; peptidyl-threonine phosphorylation; gastrulation with mouth forming second; positive regulation of bone mineralization; negative regulation of signal transduction; patterning of blood vessels; positive regulation of osteoblast differentiation; negative regulation of activin receptor signaling pathway; mesoderm formation; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of skeletal muscle development; regulation of ossification; determination of left/right symmetry; acute inflammatory response; urogenital system development; G1/S transition of mitotic cell cycle

Disease: Fibrodysplasia Ossificans Progressiva
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 Research Articles on ACVR1    1. The findings provide novel insights into the molecular mechanisms that regulate expression of the ACVR1 gene and that could be targets of new strategies for future therapeutic treatments.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACVR1 elisa kitPathways associated with ACVR1 elisa kit
 Reference Product  PubMed Publications
 SMAD1 elisa kit  >28 publications with ACVR1 and SMAD1
 BMP7 elisa kit  >18 publications with ACVR1 and BMP7
 BMP2 elisa kit  >17 publications with ACVR1 and BMP2
 SMAD5 elisa kit  >10 publications with ACVR1 and SMAD5
 ENG elisa kit  >4 publications with ACVR1 and ENG
 TGFBR1 elisa kit  >3 publications with ACVR1 and TGFBR1
 INHBB elisa kit  >1 publications with ACVR1 and INHBB
 INHBA elisa kit  >1 publications with ACVR1 and INHBA
 IKBKB elisa kit  >1 publications with ACVR1 and IKBKB
 FANCL elisa kit  >1 publications with ACVR1 and FANCL
 Products by Pathway  Pathway Diagram
 ALK1 Pathway antibodies  ALK1 Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with ACVR1 elisa kitOrgans/Tissues associated with ACVR1 elisa kit
 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >49 publications with ACVR1 and Muscular Diseases
 Myositis Ossificans Antibodies  >48 publications with ACVR1 and Myositis Ossificans
 Neoplasms Antibodies  >22 publications with ACVR1 and Neoplasms
 Vascular Diseases Antibodies  >8 publications with ACVR1 and Vascular Diseases
 Inflammation Antibodies  >8 publications with ACVR1 and Inflammation
 Nervous System Diseases Antibodies  >5 publications with ACVR1 and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >4 publications with ACVR1 and Gastrointestinal Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with ACVR1 and Cell Transformation, Neoplastic
 Intestinal Diseases Antibodies  >4 publications with ACVR1 and Intestinal Diseases
 Ovarian Neoplasms Antibodies  >3 publications with ACVR1 and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >106 publications with ACVR1 and Bone
 Muscle Antibodies  >30 publications with ACVR1 and Muscle
 Connective Tissue Antibodies  >14 publications with ACVR1 and Connective Tissue
 Vascular Antibodies  >11 publications with ACVR1 and Vascular
 Embryonic Tissue Antibodies  >11 publications with ACVR1 and Embryonic Tissue
 Blood Antibodies  >11 publications with ACVR1 and Blood
 Heart Antibodies  >8 publications with ACVR1 and Heart
 Ovary Antibodies  >7 publications with ACVR1 and Ovary
 Bone Marrow Antibodies  >6 publications with ACVR1 and Bone Marrow
 Brain Antibodies  >6 publications with ACVR1 and Brain
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