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APAF1 elisa kit :: Human adaptor molecule apoptotic peptidase activating factor 1, APAF1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS161752 APAF1 elisa kit
Unit / Price
48-Strip-Wells  /  $260 +1 FREE 8GB USB
96-Strip-Wells  /  $395 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,610 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,135 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

adaptor molecule apoptotic peptidase activating factor 1, APAF1, ELISA Kit

 Also Known As   

Human adaptor molecule apoptotic peptidase activating factor 1, APAF1 ELISA Kit

 Product Gene Name   

APAF1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for O14727
 Species Reactivity    Human
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 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of APAF1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for APAF1 purchase    MBS161752 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the adaptor molecule apoptotic peptidase activating factor 1, APAF1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing APAF1. The ELISA analytical biochemical technique of the MBS161752 kit is based on APAF1 antibody-APAF1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect APAF1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, APAF1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for APAF1. It may not necessarily be applicable to this product.
 NCBI GI #    148342475
 NCBI GeneID    317
 NCBI Accession #    ABQ59028.1 [Other Products]
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 UniProt Primary Accession #    O14727 [Other Products]
 UniProt Secondary Accession #    O43297; Q7Z438; Q9BXZ6; Q9UBZ5; Q9UGN8; Q9UGN9; Q9UGP0; Q9UJ58; Q9UJ59; Q9UJ60; B2RMX8 [Other Products]
 UniProt Related Accession #    O14727 [Other Products]
 Molecular Weight    140,745 Da
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 NCBI Official Full Name    APAF1 protein
 NCBI Official Synonym Full Names    apoptotic peptidase activating factor 1
 NCBI Official Symbol    APAF1 [Similar Products]
 NCBI Official Synonym Symbols   
CED4; APAF-1
[Similar Products]
 NCBI Protein Information    apoptotic protease-activating factor 1
 UniProt Protein Name    Apoptotic protease-activating factor 1
 Protein Family    Apoptotic protease-activating factor
 UniProt Gene Name    APAF1 [Similar Products]
 UniProt Synonym Gene Names    APAF-1 [Similar Products]
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 NCBI Summary for APAF1    This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for APAF1    Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
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 Research Articles on APAF1    1. Results suggest that low levels of Apaf-1 as an adaptor protein might be considered as a possible regulatory barrier by which differentiating cells control cell death upon rise in ROS production and cytochrome c release from mitochondria.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with APAF1 elisa kitDiseases associated with APAF1 elisa kit
 Products by Pathway  Pathway Diagram
 Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway antibodies  Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >271 publications with APAF1 and Neoplasms
 Necrosis Antibodies  >84 publications with APAF1 and Necrosis
 Carcinoma Antibodies  >79 publications with APAF1 and Carcinoma
 Nervous System Diseases Antibodies  >71 publications with APAF1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >23 publications with APAF1 and Breast Neoplasms
 Inflammation Antibodies  >20 publications with APAF1 and Inflammation
 Liver Diseases Antibodies  >19 publications with APAF1 and Liver Diseases
 Neoplasms, Experimental Antibodies  >17 publications with APAF1 and Neoplasms, Experimental
 Colonic Neoplasms Antibodies  >16 publications with APAF1 and Colonic Neoplasms
 Nerve Degeneration Antibodies  >16 publications with APAF1 and Nerve Degeneration
Organs/Tissues associated with APAF1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >93 publications with APAF1 and Brain
 Blood Antibodies  >73 publications with APAF1 and Blood
 Muscle Antibodies  >44 publications with APAF1 and Muscle
 Liver Antibodies  >39 publications with APAF1 and Liver
 Heart Antibodies  >32 publications with APAF1 and Heart
 Embryonic Tissue Antibodies  >28 publications with APAF1 and Embryonic Tissue
 Eye Antibodies  >26 publications with APAF1 and Eye
 Skin Antibodies  >24 publications with APAF1 and Skin
 Kidney Antibodies  >24 publications with APAF1 and Kidney
 Thymus Antibodies  >14 publications with APAF1 and Thymus
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