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APPL1 elisa kit :: Human adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9324161 APPL1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1), ELISA Kit

 Also Known As   

Human DCC-interacting protein 13-alpha, APPL1 ELISA Kit

 Product Synonym Names    Human DCC-interacting protein 13-alpha (APPL1) ELISA kit; APPL; DIP13alpha; AKT2 interactor; adaptor protein containing pH domain; PTB domain and leucine zipper motif 1; signaling adaptor protein DIP13alpha; adaptor protein; phosphotyrosine interaction; PH domain and leucine zipper containing 1
 Product Gene Name   

APPL1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    604299
 3D Structure    ModBase 3D Structure for Q9UKG1
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of APPL1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for APPL1 purchase    MBS9324161 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing APPL1. The ELISA analytical biochemical technique of the MBS9324161 kit is based on APPL1 antibody-APPL1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect APPL1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, APPL1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for APPL1. It may not necessarily be applicable to this product.
 NCBI GI #    6912242
 NCBI GeneID    26060
 NCBI Accession #    NP_036228.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012096.2 [Other Products]
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 UniProt Primary Accession #    Q9UKG1 [Other Products]
 UniProt Secondary Accession #    Q9P2B9 [Other Products]
 UniProt Related Accession #    Q9UKG1 [Other Products]
 Molecular Weight    79,663 Da
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 NCBI Official Full Name    DCC-interacting protein 13-alpha
 NCBI Official Synonym Full Names    adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
 NCBI Official Symbol    APPL1 [Similar Products]
 NCBI Official Synonym Symbols   
APPL; DIP13alpha
[Similar Products]
 NCBI Protein Information    DCC-interacting protein 13-alpha; dip13-alpha; AKT2 interactor; signaling adaptor protein DIP13alpha; adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
 UniProt Protein Name    DCC-interacting protein 13-alpha
 UniProt Synonym Protein Names   
Adapter protein containing PH domain, PTB domain and leucine zipper motif 1
 Protein Family    DCC-interacting protein
 UniProt Gene Name    APPL1 [Similar Products]
 UniProt Synonym Gene Names    APPL; DIP13A; KIAA1428; Dip13-alpha [Similar Products]
 UniProt Entry Name    DP13A_HUMAN
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 NCBI Summary for APPL1    The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]
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 UniProt Comments for APPL1    APPL: an effector protein of the small GTPase Rab5, a key regulator of endocytosis. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Contains a PH domain and an N-terminal PID domain. Its interaction with RAB5A/Rab5 is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Phosphorylated upon DNA damage.

Protein type: Nuclear receptor co-regulator; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: early endosome membrane; cytoplasm; endosome membrane; NuRD complex; vesicle membrane; cytosol; nucleus

Molecular Function: protein kinase B binding; identical protein binding; protein binding

Biological Process: cell proliferation; positive regulation of apoptosis; insulin receptor signaling pathway; regulation of glucose import; signal transduction; cell cycle

Disease: Maturity-onset Diabetes Of The Young, Type 14
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 Research Articles on APPL1    1. It concludes that APPL1(PH) binding to BAR domain and Reptin is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with APPL1 elisa kitPathways associated with APPL1 elisa kit
 Reference Product  PubMed Publications
 ADIPOR1 elisa kit  >20 publications with APPL1 and ADIPOR1
 APPL2 elisa kit  >14 publications with APPL1 and APPL2
 AKT2 elisa kit  >5 publications with APPL1 and AKT2
 FSHR elisa kit  >4 publications with APPL1 and FSHR
 AKT1 elisa kit  >3 publications with APPL1 and AKT1
 TRAF2 elisa kit  >1 publications with APPL1 and TRAF2
 RAB5A elisa kit  >1 publications with APPL1 and RAB5A
 DCC elisa kit  >1 publications with APPL1 and DCC
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Regulation Of Apoptosis Pathway antibodies  Regulation Of Apoptosis Pathway Diagram
 Role Of DCC In Regulating Apoptosis Pathway antibodies  Role Of DCC In Regulating Apoptosis Pathway Diagram
Diseases associated with APPL1 elisa kitOrgans/Tissues associated with APPL1 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >5 publications with APPL1 and Cardiovascular Diseases
 Inflammation Antibodies  >5 publications with APPL1 and Inflammation
 Nervous System Diseases Antibodies  >5 publications with APPL1 and Nervous System Diseases
 Vascular Diseases Antibodies  >5 publications with APPL1 and Vascular Diseases
 Kidney Diseases Antibodies  >4 publications with APPL1 and Kidney Diseases
 Necrosis Antibodies  >3 publications with APPL1 and Necrosis
 Myocardial Ischemia Antibodies  >2 publications with APPL1 and Myocardial Ischemia
 Postoperative Complications Antibodies  >2 publications with APPL1 and Postoperative Complications
 Weight Loss Antibodies  >2 publications with APPL1 and Weight Loss
 Intestinal Diseases Antibodies  >1 publications with APPL1 and Intestinal Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >22 publications with APPL1 and Muscle
 Kidney Antibodies  >6 publications with APPL1 and Kidney
 Vascular Antibodies  >6 publications with APPL1 and Vascular
 Brain Antibodies  >6 publications with APPL1 and Brain
 Embryonic Tissue Antibodies  >5 publications with APPL1 and Embryonic Tissue
 Heart Antibodies  >5 publications with APPL1 and Heart
 Liver Antibodies  >5 publications with APPL1 and Liver
 Adipose Tissue Antibodies  >4 publications with APPL1 and Adipose Tissue
 Blood Antibodies  >3 publications with APPL1 and Blood
 Bone Antibodies  >2 publications with APPL1 and Bone
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