NP_000662.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,724 Da
NCBI Official Full Name
alcohol dehydrogenase class-3
NCBI Official Synonym Full Names
alcohol dehydrogenase 5 (class III), chi polypeptide
NCBI Official Synonym Symbols
FDH; ADHX; ADH-3; FALDH; GSNOR; GSH-FDH [Similar Products]
NCBI Protein Information
alcohol dehydrogenase class-3; formaldehyde dehydrogenase; alcohol dehydrogenase class-III; alcohol dehydrogenase class chi chain; S-(hydroxymethyl)glutathione dehydrogenase; glutathione-dependent formaldehyde dehydrogenase; alcohol dehydrogenase (class III), chi polypeptide
UniProt Protein Name
Alcohol dehydrogenase class-3
UniProt Synonym Protein Names
Alcohol dehydrogenase 5; Alcohol dehydrogenase class chi chain; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-); FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
UniProt Synonym Gene Names
UniProt Entry Name
ADHX_HUMAN
NCBI Summary for ADH5
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for ADH5
ADH5: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Oxidoreductase; EC 1.1.1.1; Mitochondrial; EC 1.1.1.284; Energy Metabolism - methane; Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - fatty acid; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tyrosine
Chromosomal Location of Human Ortholog: 4q23
Cellular Component: mitochondrion; nucleus
Molecular Function: protein homodimerization activity; electron carrier activity; zinc ion binding; formaldehyde dehydrogenase activity; S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase activity; fatty acid binding
Biological Process: respiratory system process; response to nitrosative stress; ethanol catabolic process; formaldehyde catabolic process; peptidyl-cysteine S-nitrosylation; response to lipopolysaccharide; response to redox state; retinoid metabolic process; ethanol oxidation; positive regulation of blood pressure; aging
Research Articles on ADH5
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Pathways associated with ADH5 elisa kit
Diseases associated with ADH5 elisa kit
Organs/Tissues associated with ADH5 elisa kit
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