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AKR1C4 elisa kit :: Human aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9329809 AKR1C4 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) (AKR1C4), ELISA Kit

 Also Known As   

Human Aldo-keto reductase family 1 member C4, AKR1C4 ELISA Kit

 Product Synonym Names    Human Aldo-keto reductase family 1 member C4 (AKR1C4) ELISA kit; 3-alpha-HSD; C11; CDR; CHDR; DD4; HAKRA; MGC22581; 3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase 4; OTTHUMP00000018997; aldo-keto reductase family 1; member C4; chlordecone reductase; d; aldo-keto reductase family 1; member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase; type I; dihydrodiol dehydrogenase 4)
 Product Gene Name   

AKR1C4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 614279
 3D Structure    ModBase 3D Structure for P17516
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples.
 Assay Type    Sandwich
 Detection Range    0.5ng/ml-16ng/ml.
 Sensitivity    0.1ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of AKR1C4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AKR1C4 purchase    MBS9329809 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) (AKR1C4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.5ng/ml-16ng/ml in biological research samples containing AKR1C4, with an estimated sensitivity of 0.1ng/ml. The ELISA analytical biochemical technique of the MBS9329809 kit is based on AKR1C4 antibody-AKR1C4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AKR1C4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AKR1C4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for AKR1C4 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of AKR1C4 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9329809. Click to request current manual
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NCBI/Uniprot data below describe general gene information for AKR1C4. It may not necessarily be applicable to this product.
 NCBI GI #    325652083
 NCBI GeneID    1109
 NCBI Accession #    NP_001809.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001818.3 [Other Products]
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 UniProt Primary Accession #    P17516 [Other Products]
 UniProt Secondary Accession #    Q5T6A3; Q8WW84; Q9NS54 [Other Products]
 UniProt Related Accession #    P17516; AAB47003 [Other Products]
 Molecular Weight    37,067 Da
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 NCBI Official Full Name    aldo-keto reductase family 1 member C4
 NCBI Official Synonym Full Names    aldo-keto reductase family 1, member C4
 NCBI Official Symbol    AKR1C4 [Similar Products]
 NCBI Official Synonym Symbols   
C11; CDR; DD4; CHDR; DD-4; HAKRA; 3-alpha-HSD
[Similar Products]
 NCBI Protein Information    aldo-keto reductase family 1 member C4; 3-alpha-HSD1; dihydrodiol dehydrogenase isozyme DD4; type I 3-alpha-hydroxysteroid dehydrogenase; chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4
 UniProt Protein Name    Aldo-keto reductase family 1 member C4
 UniProt Synonym Protein Names   
3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase type I (EC:1.1.1.357); Chlordecone reductase (EC:1.1.1.225); CDR; Dihydrodiol dehydrogenase 4; DD-4; DD4; HAKRA
 Protein Family    Aldo-keto reductase family
 UniProt Gene Name    AKR1C4 [Similar Products]
 UniProt Synonym Gene Names    CHDR; CDR; DD-4; DD4 [Similar Products]
 UniProt Entry Name    AK1C4_HUMAN
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 NCBI Summary for AKR1C4    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AKR1C4    AKR1C4: Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. Defects in AKR1C4 are a cause of 46,XY sex reversal type 8 (SRXY8). A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. AKR1C4 mutations may act as modifier of disease severity in SRXY8 patients. A splicing mutation resulting in loss of exon 2 has been found in affected individuals also carrying mutation Val-79 in AKR1C2 (PubMed:21802064). Belongs to the aldo/keto reductase family.

Protein type: EC 1.1.1.357; EC 1.1.1.225; Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase; Lipid Metabolism - C21-steroid hormone; Xenobiotic Metabolism - metabolism by cytochrome P450; Lipid Metabolism - androgen and estrogen

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: cytoplasm; cytosol

Molecular Function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; electron carrier activity; aldo-keto reductase activity; chlordecone reductase activity; bile acid transmembrane transporter activity; retinal dehydrogenase activity; 3(or 17)-alpha-hydroxysteroid dehydrogenase activity

Biological Process: steroid metabolic process; bile acid and bile salt transport; phototransduction, visible light; bile acid biosynthetic process; bile acid metabolic process; androgen metabolic process; retinoid metabolic process

Disease: 46,xy Sex Reversal 8
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 Research Articles on AKR1C4    1. Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with AKR1C4 elisa kitDiseases associated with AKR1C4 elisa kit
 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >5 publications with AKR1C4 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >3 publications with AKR1C4 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >3 publications with AKR1C4 and Breast Neoplasms
 Hyperplasia Antibodies  >2 publications with AKR1C4 and Hyperplasia
 Endometriosis Antibodies  >2 publications with AKR1C4 and Endometriosis
 Bipolar Disorder Antibodies  >2 publications with AKR1C4 and Bipolar Disorder
 Kidney Diseases Antibodies  >1 publications with AKR1C4 and Kidney Diseases
 Kidney Neoplasms Antibodies  >1 publications with AKR1C4 and Kidney Neoplasms
 Vascular Diseases Antibodies  >1 publications with AKR1C4 and Vascular Diseases
 Mammary Neoplasms, Animal Antibodies  >1 publications with AKR1C4 and Mammary Neoplasms, Animal
Organs/Tissues associated with AKR1C4 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >23 publications with AKR1C4 and Liver
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