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APH1B elisa kit :: Human anterior pharynx defective 1 homolog B (C. elegans) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9319659 APH1B elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

anterior pharynx defective 1 homolog B (C. elegans) (APH1B), ELISA Kit

 Also Known As   

Human Gamma-secretase subunit APH-1B, APH1B ELISA Kit

 Product Synonym Names    Human Gamma-secretase subunit APH-1B (APH1B) ELISA kit; APH-1B; DKFZp564D0372; FLJ33115; PRO1328; PSFL; TAAV688; anterior pharynx defective 1B-like; presenilin stabilization factor-like; anterior pharynx defective 1 homolog B (C. elegans)
 Product Gene Name   

APH1B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    607630
 3D Structure    ModBase 3D Structure for Q8WW43
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of APH1B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for APH1B purchase    MBS9319659 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the anterior pharynx defective 1 homolog B (C. elegans) (APH1B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing APH1B. The ELISA analytical biochemical technique of the MBS9319659 kit is based on APH1B antibody-APH1B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect APH1B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, APH1B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for APH1B. It may not necessarily be applicable to this product.
 NCBI GI #    224548987
 NCBI GeneID    83464
 NCBI Accession #    NP_001139118.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145646.1 [Other Products]
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 UniProt Primary Accession #    Q8WW43 [Other Products]
 UniProt Secondary Accession #    Q564N3; Q6UWQ1; Q9H0S0; A8K589 [Other Products]
 UniProt Related Accession #    Q8WW43 [Other Products]
 Molecular Weight    28,460 Da
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 NCBI Official Full Name    gamma-secretase subunit APH-1B isoform 2
 NCBI Official Synonym Full Names    APH1B gamma secretase subunit
 NCBI Official Symbol    APH1B [Similar Products]
 NCBI Official Synonym Symbols   
PSFL; APH-1B; PRO1328; TAAV688
[Similar Products]
 NCBI Protein Information    gamma-secretase subunit APH-1B; aph-1beta; anterior pharynx defective 1 homolog B
 UniProt Protein Name    Gamma-secretase subunit APH-1B
 UniProt Synonym Protein Names   
Aph-1beta; Presenilin-stabilization factor-like
 Protein Family    Gamma-secretase
 UniProt Gene Name    APH1B [Similar Products]
 UniProt Synonym Gene Names    PSFL; UNQ688/PRO1328; APH-1b [Similar Products]
 UniProt Entry Name    APH1B_HUMAN
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 NCBI Summary for APH1B    This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
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 UniProt Comments for APH1B    APH1B: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. Belongs to the APH-1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q22.2

Cellular Component: transport vesicle; plasma membrane; integral to membrane

Molecular Function: peptidase activity; protein binding

Biological Process: positive regulation of catalytic activity; axon guidance; Notch signaling pathway; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; ephrin receptor signaling pathway; Notch receptor processing; protein processing
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 Research Articles on APH1B    1. gamma-Secretase inhibition during repeated peripheral inflammation blocks central amyloid-beta accumulation and prevents cognitive dysfunction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with APH1B elisa kitPathways associated with APH1B elisa kit
 Reference Product  PubMed Publications
 PSEN1 elisa kit  >5 publications with APH1B and PSEN1
 PSEN2 elisa kit  >4 publications with APH1B and PSEN2
 NCSTN elisa kit  >2 publications with APH1B and NCSTN
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 NRIF Signals Cell Death From The Nucleus Pathway antibodies  NRIF Signals Cell Death From The Nucleus Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Nuclear Signaling By ERBB4 Pathway antibodies  Nuclear Signaling By ERBB4 Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 Regulated Proteolysis Of P75NTR Pathway antibodies  Regulated Proteolysis Of P75NTR Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By ERBB4 Pathway antibodies  Signaling By ERBB4 Pathway Diagram
Diseases associated with APH1B elisa kitOrgans/Tissues associated with APH1B elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with APH1B and Nervous System Diseases
 Disease Models, Animal Antibodies  >5 publications with APH1B and Disease Models, Animal
 Drug Toxicity Antibodies  >1 publications with APH1B and Drug Toxicity
 Myocardial Ischemia Antibodies  >1 publications with APH1B and Myocardial Ischemia
 Necrosis Antibodies  >1 publications with APH1B and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with APH1B and Brain
 Blood Antibodies  >2 publications with APH1B and Blood
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