NP_001006667.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,020 Da
NCBI Official Full Name
DNA dC->dU-editing enzyme APOBEC-3F isoform b
NCBI Official Synonym Full Names
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
NCBI Protein Information
DNA dC->dU-editing enzyme APOBEC-3F; induced upon T-cell activation; apolipoprotein B mRNA editing enzyme cytidine deaminase; apolipoprotein B editing enzyme catalytic polypeptide-like 3F; apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F
UniProt Protein Name
DNA dC->dU-editing enzyme APOBEC-3F
UniProt Synonym Protein Names
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F; A3F
UniProt Synonym Gene Names
UniProt Entry Name
ABC3F_HUMAN
NCBI Summary for APOBEC3F
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for APOBEC3F
APOBEC3F: Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. After being packaged into HIV-1 virions, blocks productive infection by massively editing dC residues to dU on the DNA minus strand during reverse transcription. The editing of the minus strand DNA of HIV-1 during reverse transcription leads to G- to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Belongs to the cytidine and deoxycytidylate deaminase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA processing; Hydrolase; EC 3.5.4.-
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: apolipoprotein B mRNA editing enzyme complex; cytoplasm; ribonucleoprotein complex
Molecular Function: protein binding; zinc ion binding; RNA binding; cytidine deaminase activity
Biological Process: negative regulation of retroviral genome replication; base conversion or substitution editing; negative regulation of viral genome replication; innate immune response; cytidine deamination; positive regulation of defense response to virus by host; negative regulation of viral reproduction; defense response to virus
Research Articles on APOBEC3F
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Pathways associated with APOBEC3F elisa kit
Diseases associated with APOBEC3F elisa kit
Organs/Tissues associated with APOBEC3F elisa kit
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