NP_001036146.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
172,424 Da
NCBI Official Full Name
arginine-glutamic acid dipeptide repeats protein isoform a
NCBI Official Synonym Full Names
arginine-glutamic acid dipeptide (RE) repeats
NCBI Protein Information
arginine-glutamic acid dipeptide repeats protein; atrophin 2; atrophin-1 like protein; atrophin-1-like protein; atrophin-1 related protein; atrophin-1-related protein
UniProt Protein Name
Arginine-glutamic acid dipeptide repeats protein
UniProt Synonym Protein Names
Atrophin-1-like protein; Atrophin-1-related protein
UniProt Synonym Gene Names
UniProt Entry Name
RERE_HUMAN
NCBI Summary for RERE
This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for RERE
RERE: Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. A chromosomal aberration involving RERE is found in the neuroblastoma cell line. Translocation t(1;15)(p36.2;q24). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 1p36.23
Cellular Component: histone deacetylase complex; nucleus
Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding; poly-glutamine tract binding; chromatin binding; transcription factor activity
Biological Process: chromatin remodeling; regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; NLS-bearing substrate import into nucleus
Research Articles on RERE
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Products associated with RERE elisa kit
Diseases associated with RERE elisa kit
Organs/Tissues associated with RERE elisa kit
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