NP_001158095.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
93,620 Da
NCBI Official Full Name
protein argonaute-2 isoform 2
NCBI Official Synonym Full Names
argonaute 2, RISC catalytic component
NCBI Official Synonym Symbols
PPD; Q10; CASC7; EIF2C2; LINC00980 [Similar Products]
NCBI Protein Information
protein argonaute-2
UniProt Protein Name
Protein argonaute-2
UniProt Synonym Protein Names
Argonaute RISC catalytic component 2; Eukaryotic translation initiation factor 2C 2
UniProt Synonym Gene Names
NCBI Summary for EIF2C2
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for EIF2C2
AGO2: the endonuclease in RNA-induced silencing complexes (RISC) that cleaves siRNA/mRNA heteroduplexes bound to RISC. Ago2, along with Dicer and TRBP, are major components of RISC. Interacts with Dicer1 through its Piwi domain. Required for proper fibroblast growth factor signaling during gastrulation. Essential for embryonic development as well as RNA-mediated gene silencing (RNAi).
Protein type: EC 3.1.26.n2; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: cell junction; cytoplasm; cytosol; membrane; mRNA cap complex; nucleoplasm; nucleus; polysome; ribonucleoprotein complex
Molecular Function: double-stranded RNA binding; endoribonuclease activity; miRNA binding; protein binding; protein C-terminus binding; RNA 7-methylguanosine cap binding; RNA binding; single-stranded RNA binding; siRNA binding
Biological Process: miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, negative regulation of translation; miRNA-mediated gene silencing, production of miRNAs; negative regulation of translational initiation; phosphoinositide-mediated signaling; positive regulation of transcription from RNA polymerase II promoter; pre-microRNA processing; RNA interference, production of siRNA; RNA interference, siRNA loading onto RISC; RNA secondary structure unwinding; RNA-mediated gene silencing; RNA-mediated posttranscriptional gene silencing; Wnt receptor signaling pathway, calcium modulating pathway
Research Articles on EIF2C2
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Organs/Tissues associated with EIF2C2 elisa kit
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