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ARRB1 elisa kit :: Human arrestin, beta 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9334094 ARRB1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

arrestin, beta 1 (ARRB1), ELISA Kit

★Popular Item★
 Also Known As   

Human Beta-arrestin-1, ARRB1 ELISA Kit

 Product Synonym Names    Human Beta-arrestin-1 (ARRB1) ELISA kit; ARB1; ARR1; arrestin 2; arrestin beta 1; beta-arrestin; arrestin; beta 1
 Product Gene Name   

ARRB1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    107940
 3D Structure    ModBase 3D Structure for P49407
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    0.25 ng/ml - 8 ng/ml
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ARRB1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ARRB1 purchase    MBS9334094 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the arrestin, beta 1 (ARRB1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.25 ng/ml - 8 ng/ml in biological research samples containing ARRB1, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9334094 kit is based on ARRB1 antibody-ARRB1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ARRB1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ARRB1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ARRB1 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ARRB1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9334094. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ARRB1. It may not necessarily be applicable to this product.
 NCBI GI #    10880136
 NCBI GeneID    408
 NCBI Accession #    NP_004032.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004041.4 [Other Products]
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 UniProt Primary Accession #    P49407 [Other Products]
 UniProt Secondary Accession #    O75625; O75630; Q2PP20; Q9BTK8; B6V9G8 [Other Products]
 UniProt Related Accession #    P49407 [Other Products]
 Molecular Weight    47,066 Da
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 NCBI Official Full Name    beta-arrestin-1 isoform A
 NCBI Official Synonym Full Names    arrestin, beta 1
 NCBI Official Symbol    ARRB1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    beta-arrestin-1; arrestin 2
 UniProt Protein Name    Beta-arrestin-1
 UniProt Synonym Protein Names   
Arrestin beta-1
 Protein Family    Beta-arrestin
 UniProt Gene Name    ARRB1 [Similar Products]
 UniProt Synonym Gene Names    ARR1 [Similar Products]
 UniProt Entry Name    ARRB1_HUMAN
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 NCBI Summary for ARRB1    Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
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 UniProt Comments for ARRB1    ARRB1: regulates G-protein coupled receptors (GPCR) signaling by mediating both receptor desensitization and resensitization processes. Binds to GRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require receptor determinants exposed only in the active receptor conformation. Targets many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins). Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6). Involved in IL8-mediated granule release in neutrophils. Interacts with phosphorylated ADRB2 and CHRM2. Interacts with SRC (via the SH3 domain and the protein kinase domain); the interaction is independent of the phosphorylation state of SRC C-terminus. Interacts with RAF1, CHUK, IKBKB and Nik. Interacts with DVL1 and DVL2; the interaction is enhanced by DVL phosphorylation. Interacts with IGF1R. Belongs to the arrestin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytoplasmic vesicle membrane; lysosomal membrane; coated pit; pseudopodium; cytosol; nucleoplasm; Golgi membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; cytoplasmic vesicle; nucleus; chromatin

Molecular Function: angiotensin receptor binding; enzyme inhibitor activity; insulin-like growth factor receptor binding; protein binding; histone acetyltransferase activity; mitogen-activated protein kinase kinase binding; ubiquitin protein ligase binding; caspase inhibitor activity; transcription factor binding; GTPase activator activity

Biological Process: transcription from RNA polymerase II promoter; platelet activation; proteasomal ubiquitin-dependent protein catabolic process; Notch signaling pathway; positive regulation of protein binding; positive regulation of receptor internalization; positive regulation of Rho protein signal transduction; protein ubiquitination; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; protein transport; G-protein coupled receptor internalization; inhibition of NF-kappaB transcription factor; negative regulation of interleukin-8 production; negative regulation of interleukin-6 production; phototransduction; stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein ubiquitination; positive regulation of histone acetylation; positive regulation of protein amino acid phosphorylation; post-Golgi vesicle-mediated transport; blood coagulation; positive regulation of GTPase activity
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 Research Articles on ARRB1    1. Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ARRB1 elisa kitPathways associated with ARRB1 elisa kit
 Reference Product  PubMed Publications
 ADRB2 elisa kit  >2 publications with ARRB1 and ADRB2
 ADRB1 elisa kit  >1 publications with ARRB1 and ADRB1
 MDM2 elisa kit  >1 publications with ARRB1 and MDM2
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with ARRB1 elisa kitOrgans/Tissues associated with ARRB1 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with ARRB1 and Inflammation
 Breast Neoplasms Antibodies  >1 publications with ARRB1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >1 publications with ARRB1 and Lung Neoplasms
 Brain Diseases Antibodies  >1 publications with ARRB1 and Brain Diseases
 Liver Neoplasms Antibodies  >1 publications with ARRB1 and Liver Neoplasms
 Nervous System Diseases Antibodies  >1 publications with ARRB1 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with ARRB1 and Liver Diseases
 Hypertension Antibodies  >1 publications with ARRB1 and Hypertension
 Carcinoma, Hepatocellular Antibodies  >1 publications with ARRB1 and Carcinoma, Hepatocellular
 Fibrosis Antibodies  >1 publications with ARRB1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with ARRB1 and Lung
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