NP_001171476.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,354 Da
NCBI Official Full Name
S-methylmethionine--homocysteine S-methyltransferase BHMT2 isoform 2
NCBI Official Synonym Full Names
betaine--homocysteine S-methyltransferase 2
NCBI Protein Information
S-methylmethionine--homocysteine S-methyltransferase BHMT2; SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2
UniProt Protein Name
S-methylmethionine--homocysteine S-methyltransferase BHMT2
UniProt Synonym Protein Names
Betaine--homocysteine S-methyltransferase 2
UniProt Synonym Gene Names
UniProt Entry Name
BHMT2_HUMAN
NCBI Summary for BHMT2
Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
UniProt Comments for BHMT2
BHMT2: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; EC 2.1.1.10
Chromosomal Location of Human Ortholog: 5q13
Cellular Component: cytosol
Molecular Function: betaine-homocysteine S-methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion binding
Biological Process: methylation; S-methylmethionine cycle; S-methylmethionine metabolic process; S-adenosylmethionine metabolic process; betaine metabolic process
Research Articles on BHMT2
Precautions
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Pathways associated with BHMT2 elisa kit
Diseases associated with BHMT2 elisa kit
Organs/Tissues associated with BHMT2 elisa kit
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